ArticleInternational journal of clinical and experimental medicine2015
Association between vitamin D deficiency and insufficiency and the risk of childhood asthma: evidence from a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effects of vitamin D levels and vitamin D supplementation on allergic diseases: an umbrella review.Frontiers in allergy · 2026Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.Nutrients · 2020Pooled it
- Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis.Nutrients · 2018Pooled it
- Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.PLoS medicine · 2017Pooled it
- Association of free vitamin DAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Trial
- Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- The potential of anti-infectives and immunomodulators as therapies for asthma and asthma exacerbations.Allergy · 2018Review
- Are children's vitamin D levels and BMI associated with antibody titers produced in response to 2014-2015 influenza vaccine?Human vaccines & immunotherapeutics · 2017Article
- The impact of vitamin D on asthmatic human airway smooth muscle.Expert review of respiratory medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWhether vitamin D deficiency and insufficiency are associated with childhood asthma remains unclear. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin D deficiency and insufficiency and the risk of childhood asthma.
methodsPertinent studies were identified by searching of PubMed and Web of Knowledge. The random effect model was used to combine the results. Meta-regression and subgroups analyses were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using Egger's regression asymmetry test.
resultsFinally, 14 articles with 15 studies including 3424 cases for vitamin D deficiency and 9 articles with 10 studies including 2756 cases for vitamin D insufficiency were included in this meta-analysis. The relative risk (95% confidence interval) of childhood asthma risk for vitamin D deficiency was 1.684 (1.321-2.148), and the associations were significant in America and Europe. Significant association of childhood asthma between vitamin D insufficiency and childhood asthma risk was found overall [1.577 (1.230-2.023)] and the subgroups of America, Europe and Asia. No evidence of significant publication bias between vitamin D deficiency and insufficiency and childhood asthma risk were found.
conclusionsResults from this meta-analysis suggested that vitamin D deficiency and insufficiency might increase the risk of childhood asthma.
Indexed as
Identifiers
26131154PMC4483990What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.