ArticleInternational journal of clinical and experimental medicine2015
The association between the FABP2 Ala54Thr variant and the risk of type 2 diabetes mellitus: a meta-analysis based on 11 case-control studies.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Postprandial Hypertriglyceridemia Is Associated with the Variant 54 ThreonineJournal of cardiovascular development and disease · 2018Article
- Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate.International journal of molecular sciences · 2017Review
- The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes.International journal of environmental research and public health · 2015Article
- GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.Frontiers in endocrinology · 2015Article
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Authors and funding
8 authors.
Funding
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Abstract
Fatty acid binding protein 2 (FABP2) Ala54Thr gene polymorphism has been suggested to be associated with the increased risk of developing type 2 diabetes mellitus (T2DM), but some studies show the inconsistent result. The purpose of this meta-analysis is to assess the association between FABP2 Ala54Thr gene polymorphism variants and the T2DM. A total of 7095 subjects in 11 case-control studies were included in this meta-analysis. Under the allele model (T versus A), the pooled OR of Asian subgroup was 1.19 (95% CI = 1.06-1.32, P = 0.002). Under the recessive model (TT versus AA + AT), the pooled OR of Asian subgroup was 1.34 (95% CI = 1.05-1.71, P = 0.02). Under the dominant model (TT + AT versus AA), the pooled OR was 1.14 (95% CI = 1.03-1.27, P = 0.01) and when the analysis stratified by region, increased risks were identified among Asian (OR = 1.20, 95% CI = 1.05-1.38, P = 0.009). Under the codominant model (TT versus AA), no significant association was found. Under the codominant model (AT versus AA), the pooled OR was 1.14 (95% CI = 1.02-1.27, P = 0.02). It is indicated that the variant T allele carrier may increased the risk of T2DM and the risk is related to race.
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Registered trials
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