Evidence map›Paper›PMID 26131010›Full record

ArticleIranian journal of reproductive medicine2015

SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique.

Eskandar Taghizadeh, Seyed Mehdi Kalantar, Reza Mahdian, Mohammad Hasan Sheikhha, Ehsan Farashahi-Yazd, Saeed Ghasemi, Zahra Shahbazi

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Article in Iranian journal of reproductive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Eskandar TaghizadehDepartment of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Mehdi KalantarResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Reza MahdianDepartment of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Mohammad Hasan SheikhhaDepartment of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Ehsan Farashahi-YazdDepartment of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Saeed GhasemiDepartment of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Zahra ShahbaziPasteur Institute of Iran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.

objectiveStudy of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique. MATERIALS AND

methodsWe studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.

resultsWe found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).

conclusionThese findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.

Indexed as

Polymerase chain reactionRestriction endonucleasesRestriction fragment length Polymorphysmrs6990375Single nucleotide polymorphismSULF1 gene

Identifiers

PMID26131010
PMCPMC4475770

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