ArticlePharmacognosy research
Chemopreventive effect of methanolic extract of Azadirachta indica on experimental Trypanosoma brucei induced oxidative stress in dogs.
Article in Pharmacognosy research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 9 citations in OpenAlex.
- Coinfection withJournal of tropical medicine · 2023Article
- Oxidative stress changes observed in selected organs of African giant rats (International journal of veterinary science and medicine · 2018Article
- Evaluation of oxidative stress in caprine bronchoalveolar lavage fluid of pneumonic and normal lungs.International journal of veterinary science and medicine · 2017Article
- Effect of isoflurane + NExperimental and therapeutic medicine · 2017Article
- Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling.Journal of Ayurveda and integrative medicineArticle
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4 authors at 1 institution in 1 country.
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Abstract
introductionThe medicinal properties of Azadirachta indica have been harnessed for many years in the treatment of many diseases in both humans and animals. MATERIALS AND
methodsTwenty-five apparently healthy dogs weighing between 3 and 8 kg were randomly divided into five groups with five dogs in each group. Ameliorative effect of A. indica on erythrocyte antioxidant status and markers of oxidative stress were assessed. Liver and kidney function tests were also performed.
resultsPre-treatment with methanolic extract of Azadirachta indica (MEAI) at different doses did not significantly alter the values of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity in Trypanosoma brucei infection. Although, serum creatinine significantly (P < 0.05) decreased with pre-treatment with 50 mg/kg A. indica, after 2 weeks of T. brucei infection. However, the reduced glutathione (GSH) content of the erythrocyte increased significantly in animals pre-treated with 50 mg/kg and 200 mg/kg of A. indica respectively. Markers of oxidative stress such as malondialdehyde and hydrogen peroxide generated were higher in animals infected with T. brucei with no significant (P >0.05) difference compared to the values obtained in pre-treated animals. Pre-treatment with 100 mg/kg and 200 mg/kg of A. indica significantly (P < 0.05) decreased serum myeloperoxidase activity at 2 weeks post-infection with T. brucei.
conclusionFrom this study, MEAI showed significant ability to attenuate oxidative stress and inflammation during experimental T. brucei infection.
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