ArticleScientific reports2015
High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026Review
- Toward noninvasive optoacoustic imaging of whole-heart dynamics in mice.Light, science & applications · 2025Article
- Optical theranostics in ischemic heart disease: from molecular insights to clinical translation.Theranostics · 2025Review
- Cardiac-gated spectroscopic photoacoustic imaging for ablation-induced necrotic lesion visualization.Journal of biophotonics · 2024Article
- Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Spiral volumetric optoacoustic tomography for imaging whole-body biodynamics in small animals.Nature protocols · 2023Review
- Photoacoustic tomography reveals structural and functional cardiac images of animal models.Light, science & applications · 2023Article
- Deep Learning Enhances Multiparametric Dynamic Volumetric Photoacoustic Computed Tomography In Vivo (DL-PACT).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Subaperture Processing-Based Adaptive Beamforming for Photoacoustic Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Perspective on fast-evolving photoacoustic tomography.Journal of biomedical optics · 2021Article
- Spatiotemporal Coherence Weighting for In Vivo Cardiac Photoacoustic Image Beamformation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.Frontiers in physiology · 2021Review
- Volumetric Optoacoustic Tomography Differentiates Myocardial Remodelling.Molecular imaging and biology · 2020Article
- Optoacoustic model-based inversion using anisotropic adaptive total-variation regularization.Photoacoustics · 2019Article
- Volumetric optoacoustic tomography enables non-invasive in vivo characterization of impaired heart function in hypoxic conditions.Scientific reports · 2019Article
- Cardiovascular optoacoustics: From mice to men - A review.Photoacoustics · 2019Review
- Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.Light, science & applications · 2019Article
- Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Medicinal research reviews · 2018Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional imaging of mouse models of cardiac health and disease provides a major contribution to our fundamental understanding of the mammalian heart. However, imaging murine hearts presents significant challenges due to their small size and rapid heart rate. Here we demonstrate the feasibility of high-frame-rate, noninvasive optoacoustic imaging of the murine heart. The temporal resolution of 50 three-dimensional frames per second provides functional information at important phases of the cardiac cycle without the use of gating or other motion-reduction methods. Differentiation of the blood oxygenation state in the heart chambers was enabled by exploiting the wavelength dependence of optoacoustic signals. Real-time volumetric tracking of blood perfusion in the cardiac chambers was also evaluated using indocyanine green. Taken together, the newly-discovered capacities offer a unique tool set for in-vivo structural and functional imaging of the whole heart with high spatio-temporal resolution in all three dimensions.
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