Evidence map›Paper›PMID 26130328›Full record

ArticleOphthalmology2015

The Significance of the Discordant Occurrence of Lens Tumors in Humans versus Other Species.

Daniel M Albert, Paul O Phelps, Krishna R Surapaneni, Bradley A Thuro, Heather A D Potter, Akihiro Ikeda, Leandro B C Teixeira, Richard R Dubielzig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Optic nerve meningioma and cloacal adenocarcinoma in a Humboldt penguin.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
    Article
  2. Article
  3. Article
  4. The lens growth process.Progress in retinal and eye research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel M AlbertDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin. Electronic address: dalbert@wisc.edu.
Paul O PhelpsDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin.
Krishna R SurapaneniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin.
Bradley A ThuroDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin.
Heather A D PotterDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin.
Akihiro IkedaMcPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin; Department of Medical Genetics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Leandro B C TeixeiraMcPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.
Richard R DubielzigDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.
University of Wisconsin–Madison · USSmith-Kettlewell Eye Research Institute · US

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
NEI NIH HHS P30 EY016665
6 · The paper itself

Abstract

purposeThe purpose of this study was to determine in which species and under what conditions lens tumors occur.

designA review of databases of available human and veterinary ocular pathologic material and the previously reported literature.

participantsApproximately 18 000 patients who had ocular surgical specimens submitted and studied at the University of Wisconsin School of Medicine and Public Health between 1920 and 2014 and 45 000 ocular veterinary cases from the Comparative Ocular Pathology Laboratory of Wisconsin between 1983 and 2014.

methodsMaterial in 2 major archived collections at the University of Wisconsin medical and veterinary schools were studied for occurrence of lens tumors. Tumor was defined as a new growth of tissue characterized by progressive, uncontrolled proliferation of cells. In addition, cases presented at 3 major eye pathologic societies (Verhoeff-Zimmerman Ophthalmic Pathology Society, Eastern Ophthalmic Pathology Society, and The Armed Forces Institute of Pathology Ophthalmic Alumni Society) from 1975 through 2014 were reviewed. Finally, a careful search of the literature was carried out. Approval from the institutional review board to carry out this study was obtained.

main outcome measuresThe presence of tumors of the lens.

resultsThe database search and literature review failed to find an example of a lens tumor in humans. In contrast, examples of naturally occurring lens tumors were found in cats, dogs, rabbits, and birds. In the veterinary school database, 4.5% of feline intraocular and adnexal neoplasms (234/5153) were designated as feline ocular posttraumatic sarcoma, a tumor previously demonstrated to be of lens epithelial origin. Similar tumors were seen in rabbit eyes, a bird, and in a dog. All 4 species with lens tumors had a history of either ocular trauma or protracted uveitis. The literature search also revealed cases where lens tumors were induced in zebrafish, rainbow trout, hamsters, and mice by carcinogenic agents (methylcholanthrene, thioacetamide), oncogenic viruses (SV40, HPV-16), and genetic manipulation.

conclusionsOur results suggest that lens tumors do not occur in humans. In contrast, after lens capsule rupture, a lens tumor can occur in other species. We hypothesize that a genetic mechanism exists that prevents lens tumors in humans.

Indexed as

AnimalsCatsCricetinaeDatabases, FactualDogsEye NeoplasmsFemaleHuman papillomavirus 16HumansLens DiseasesMaleMiceMice, TransgenicOncorhynchus mykissRabbitsSimian virus 40

Identifiers

PMID26130328
PMCPMC4549210
OpenAlexW1538786855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.