Evidence map›Paper›PMID 26130324›Full record

ArticleEuropean journal of nutrition2016

Association between inflammatory potential of diet and mortality in the Iowa Women's Health study.

Nitin Shivappa, Cindy K Blair, Anna E Prizment, David R Jacobs, Susan E Steck, James R Hébert

Open access · greenAbstract read
In one paragraph

Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  14. Pro-Inflammatory Dietary Patterns Are Associated With Dyslipidemia, Poor Body Composition, and Sleep Quality Among Healthcare Workers: A Cross-Sectional Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nitin ShivappaCancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA. shivappa@email.sc.edu.
Cindy K BlairDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Anna E PrizmentDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Susan E SteckCancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA.
James R HébertCancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA.
University of Minnesota · USUniversity of South Carolina · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0M
Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
NCATS NIH HHS UL1 TR000114NCI NIH HHS R01 CA039742NIDDK NIH HHS R44 DK103377
6 · The paper itself

Abstract

purposeChronic diseases such as cancer and cardiovascular disease (CVD) are well-established causes of disability and premature deaths. Dietary components that are known to affect chronic inflammation have been implicated in the etiology and prognosis of these chronic diseases. We examined the ability of the dietary inflammatory index (DII) to predict overall, cancer and CVD mortality in the Iowa Women's Health study.

methodsThe DII was computed from baseline dietary intake assessed in this cohort of 37,525 women, who were aged 55-69 years when enrolled starting in 1986. During the follow-up period, through December 31, 2010, in a total of 17,793 deaths, 5044 cancer- and 6528 CVD-related deaths were identified through mortality record linkage. Cox proportional hazards regression was used to estimate hazard ratios (HR) with DII expressed both as a continuous variable and as quartiles.

resultsComparing subjects in DII Quartile 4 versus Quartile 1, modest positive associations were noted for all-cause mortality (HRQ4vsQ1 1.07; 95 % CI 1.01-1.13; p-trend = 0.006), digestive cancer mortality (HRQ4vsQ1 1.19; 95 % CI 1.00-1.43; p-trend = 0.05), CVD mortality (HRQ4vsQ1 1.09; 95 % CI 1.01-1.18; p-trend = 0.08), non-cancer/non-CVD/non-acute mortality (HRQ4vsQ1 1.09; 95 % CI 1.00-1.19; p-trend = 0.19), coronary heart disease (CHD) mortality (HRQ4vsQ1 1.17; 95 % CI 1.05-1.30; p-trend = 0.001) and chronic obstructive pulmonary disease (COPD) mortality (HRQ4vsQ1 1.43; 95 % CI 1.18-1.75; p-trend = 0.0006). No substantial associations were observed for mortality from stroke, Alzheimer's disease or unspecified dementia.

conclusionThese results indicate that a pro-inflammatory diet, as evidenced by higher DII scores, may be associated with total mortality as well as mortality from digestive cancer, CVD, CHD and COPD.

Indexed as

DietWomen's HealthAgedAlzheimer DiseaseCardiovascular DiseasesChronic DiseaseEnergy IntakeFemaleFollow-Up StudiesHumansInflammationIowaMiddle AgedNeoplasmsNutrition AssessmentNutrition SurveysCohortDietInflammationMortalityWomen

Identifiers

PMID26130324
PMCPMC4892110
OpenAlexW1766889079

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.