Evidence map›Paper›PMID 26130257›Full record

ArticleJournal of dental research2015

Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice.

Y Soenjaya, B L Foster, F H Nociti, M Ao, D W Holdsworth, G K Hunter, M J Somerman, H A Goldberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. The role of bone sialoprotein in bone healing.Journal of structural biology · 2024
    Review
  6. Article
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  8. Infigratinib, a selective FGFR1-3 tyrosine kinase inhibitor, alters dentoalveolar development at high doses.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization.Biochemical and biophysical research communications · 2021
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Y SoenjayaBiomedical Engineering Program, University of Western Ontario, London, Canada School of Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
B L FosterNational Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
F H NocitiNational Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry, Campinas State University, Piracicaba, Brazil.
M AoNational Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
D W HoldsworthBiomedical Engineering Program, University of Western Ontario, London, Canada School of Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Canada.
G K HunterBiomedical Engineering Program, University of Western Ontario, London, Canada School of Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada Deparment of Biochemistry, University of Western Ontario, London, Canada.
M J SomermanNational Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
H A GoldbergBiomedical Engineering Program, University of Western Ontario, London, Canada School of Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada Deparment of Biochemistry, University of Western Ontario, London, Canada hagoldbe@uwo.ca.
Western University · CANational Institutes of Health · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Laboratory of Oral Connective Tissue BiologyZIAAR041196 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI SOMERMAN, MARTHA · 2013 to 2021
$8.9M
Extracellular Matrix and Phosphate/Pyrophosphate Metabolism in Cementum FormationR00AR066110 · NIAMS · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2015 to 2017
$747k
Canadian Institutes of Health Research FRN130572Intramural NIH HHSNIAMS NIH HHS AR 066110NIAMS NIH HHS R00 AR066110
6 · The paper itself

Abstract

Bone sialoprotein (BSP) is an acidic phosphoprotein with collagen-binding, cell attachment, and hydroxyapatite-nucleating properties. BSP expression in mineralized tissues is upregulated at onset of mineralization. Bsp-null (Bsp(-/-)) mice exhibit reductions in bone mineral density, bone turnover, osteoclast activation, and impaired bone healing. Furthermore, Bsp(-/-) mice have marked periodontal tissue breakdown, with a lack of acellular cementum leading to periodontal ligament detachment, extensive alveolar bone and tooth root resorption, and incisor malocclusion. We hypothesized that altered mechanical stress from mastication contributes to periodontal destruction observed in Bsp(-/-) mice. This hypothesis was tested by comparing Bsp(-/-) and wild-type mice fed with standard hard pellet diet or soft powder diet. Dentoalveolar tissues were analyzed using histology and micro-computed tomography. By 8 wk of age, Bsp(-/-) mice exhibited molar and incisor malocclusion regardless of diet. Bsp(-/-) mice with hard pellet diet exhibited high incidence (30%) of severe incisor malocclusion, 10% lower body weight, 3% reduced femur length, and 30% elevated serum alkaline phosphatase activity compared to wild type. Soft powder diet reduced severe incisor malocclusion incidence to 3% in Bsp(-/-) mice, supporting the hypothesis that occlusal loading contributed to the malocclusion phenotype. Furthermore, Bsp(-/-) mice in the soft powder diet group featured normal body weight, long bone length, and serum alkaline phosphatase activity, suggesting that tooth dysfunction and malnutrition contribute to growth and skeletal defects reported in Bsp(-/-) mice. Bsp(-/-) incisors also erupt at a slower rate, which likely leads to the observed thickened dentin and enhanced mineralization of dentin and enamel toward the apical end. We propose that the decrease in eruption rate is due to a lack of acellular cementum and associated defective periodontal attachment. These data demonstrate the importance of BSP in maintaining proper periodontal function and alveolar bone remodeling and point to dental dysfunction as causative factor of skeletal defects observed in Bsp(-/-) mice.

Indexed as

AnimalsIntegrin-Binding SialoproteinMiceMice, KnockoutPeriodontiumIntegrin-Binding Sialoproteinbonebone sialoproteincementummalocclusionmechanotransductionperiodontal ligament

Identifiers

PMID26130257
PMCPMC4547315
OpenAlexW1869618388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.