ArticleInternational journal of radiation oncology, biology, physics2015
Combined Modality Management of Retroperitoneal Sarcomas: A Single-Institution Series of 121 Patients.
Article in International journal of radiation oncology, biology, physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Intensity modulated radiation therapy and surgery for Management of Retroperitoneal Sarcomas: a single-institution experience.Radiation oncology (London, England) · 2017Trial
- Review
- Radiation therapy for retroperitoneal sarcoma: practice patterns in North America.Radiation oncology (London, England) · 2024Article
- Radiation Therapy for Retroperitoneal Sarcomas: A Strass-Ful Situation.Current oncology (Toronto, Ont.) · 2023Review
- Radiation Therapy for Soft Tissue Sarcoma: Indications, Timing, Benefits, and Consequences.The Surgical clinics of North America · 2022Review
- National Trends in Treatment for Retroperitoneal Soft Tissue Sarcoma: A Modern Appraisal of Variability in Therapeutic Strategies.Annals of surgical oncology · 2022Article
- Role of Radiation Therapy for Newly Diagnosed Retroperitoneal Sarcoma.Current treatment options in oncology · 2021Review
- Abscopal Effect Following Proton Beam Radiotherapy in a Patient With Inoperable Metastatic Retroperitoneal Sarcoma.Frontiers in oncology · 2019Article
- Efficacy of Postoperative Radiotherapy Using Modern Techniques in Patients with Retroperitoneal Soft Tissue Sarcoma.Yonsei medical journal · 2018Article
- Surgery for Abdominal Well-Differentiated Liposarcoma.Current treatment options in oncology · 2018Review
- The role of radiotherapy in the management of localized soft tissue sarcomas.Cancer biology & medicine · 2016Article
- Retroperitoneal soft-tissue sarcomas: Radiotherapy experience from a tertiary cancer center and review of current evidence.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
- Retroperitoneal or mesenteric primary liposarcoma: clinical and prognostic evaluations on five cases.Il Giornale di chirurgiaObservational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this study was to investigate local control, survival outcomes, and complication rates of patients treated with aggressive surgery and radiation therapy (RT) for retroperitoneal sarcomas (RPS). METHODS AND MATERIALS: We reviewed the medical records of 121 consecutive patients treated for RPS with surgery and RT between 1965 and 2012. The most common histology was liposarcoma (n = 42; 35%). The median follow-up was 100 months (range: 20-467 months). Eighty-six patients (71%) were treated for initial presentation of RPS, and 35 patients (29%) presented with and were treated for RPS recurrence. RT was preoperative in 88 patients (73%; median dose: 50.4 Gy) and postoperative in 33 patients (27%; median dose: 55 Gy).
resultsFive-year local control and overall survival rates were 56% and 57%, respectively. Two factors were associated with higher risk of any intra-abdominal recurrence at 5 years: positive or uncertain margins (58% vs 30% for negative margins, P < .001; hazard ratio [HR]: 2.7; 95% confidence interval [CI]: 1.6-4.8) and disease recurrence after previous resection (76% vs 31% for de novo RPS, P < .001; HR: 4.4; 95% CI: 2.5-7.5). The 10-year complication rate was 5%, and RT-related complications were associated with postoperative RT (P < .001) and RT dose of ≥ 60 Gy (P < .001).
conclusionsIntra-abdominal RPS recurrence continues to be a significant challenge despite the use of aggressive surgery and radiation therapy. Given the complications associated with postoperative radiation therapy, we recommend that preoperative radiation therapy is the preferred strategy when combined modality therapy is recommended.
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