Evidence map›Paper›PMID 26130211›Full record

SynthesisDepression and anxiety2015

A META-ANALYSIS OF COGNITIVE BEHAVIOR THERAPY AND MEDICATION FOR CHILD OBSESSIVE-COMPULSIVE DISORDER: MODERATORS OF TREATMENT EFFICACY, RESPONSE, AND REMISSION.

Joseph F McGuire, John Piacentini, Adam B Lewin, Erin A Brennan, Tanya K Murphy, Eric A Storch

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Depression and anxiety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07570108 (Precision Functional Mapping to Predict and Track ERP Response in Pediatric Obsessive-Compulsive Disorder), which is not on this map. Cited by 100 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 5 pooled it
30.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07570108 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Precision Functional Mapping to Predict and Track ERP Response in Pediatric Obsessive-Compulsive Disorder: A Longitudinal fMRI Study

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2026 to 2031Enrolled0ConditionsObsessive-Compulsive DisorderArmsExposure and Response Prevention Therapy, Clinical Assessments, Research MRI Sessions
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 5 syntheses or guidelines pooled it, 314 citations in OpenAlex.

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  17. Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
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  19. Fear conditioning and extinction in pediatric obsessive-compulsive disorder.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2017
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Joseph F McGuireDepartment of Psychology, University of South Florida, Tampa, Florida.
John PiacentiniSemel Institute of Neuroscience and Human Behavior, University of California Los Angeles, California, Los Angeles.
Adam B LewinDepartment of Psychology, University of South Florida, Tampa, Florida.
Erin A BrennanDepartment of Pediatrics, University of South Florida, Tampa, Florida.
Tanya K MurphyDepartment of Pediatrics, University of South Florida, Tampa, Florida.
Eric A StorchDepartment of Psychology, University of South Florida, Tampa, Florida.
University of South Florida · USTampa Bay Research Institute · USUniversity of California, Los Angeles · US

Funding

1/2-D-Cycloserine Augmentation of CBT for Pediatric OCDR01MH093381 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI STORCH, ERIC A. · 2011 to 2014
$1.2M
NIMH NIH HHS R01 MH093381NIMH NIH HHS R01MH093381
6 · The paper itself

Abstract

backgroundIndividual randomized controlled trials (RCTs) have demonstrated the efficacy of cognitive behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) for the treatment of youth with obsessive-compulsive disorder (OCD). Although meta-analyses have confirmed these results, there has been minimal examination of treatment moderators or an examination of treatment response and symptom/diagnostic remission for these two treatment types. The present report examined the treatment efficacy, treatment response, and symptom/diagnostic remission for youth with OCD receiving either CBT or SRIs relative to comparison conditions, and examined treatment moderators.

methodA comprehensive literature search identified 20 RCTs that met inclusion criteria, and produced a sample size of 507 CBT participants and 789 SRI participants.

resultsRandom effects meta-analyses of CBT trials found large treatment effects for treatment efficacy (g = 1.21), treatment response (relative risk [RR] = 3.93), and symptom/diagnostic remission (RR = 5.40). Greater co-occurring anxiety disorders, therapeutic contact, and lower treatment attrition were associated with greater CBT effects. The number needed to treat (NNT) was three for treatment response and symptom/diagnostic remission. Random effects meta-analyses of SRI trials found a moderate treatment effect for treatment efficacy (g = 0.50), treatment response (RR = 1.80), and symptom/diagnostic remission (RR = 2.06). Greater methodological quality was associated with a lower treatment response for SRI trials. The NNT was five for treatment response and symptom/diagnostic remission.

conclusionsFindings demonstrate the treatment effects for CBT and SRIs across three important outcome metrics, and provide evidence for moderators of CBT across trials.

Indexed as

Outcome Assessment, Health CareAdolescentChildChild, PreschoolCognitive Behavioral TherapyCombined Modality TherapyHumansObsessive-Compulsive DisorderRemission InductionSelective Serotonin Reuptake InhibitorsSelective Serotonin Reuptake Inhibitorsclomipraminecognitive behavior therapydiagnostic remissionobsessive-compulsive disorderselective serotonin reuptake inhibitorstreatment outcometreatment response

Identifiers

PMID26130211
PMCPMC4515191
OpenAlexW1541501625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.