ArticleEuropean journal of epidemiology2016
Personality traits and the risk for Parkinson disease: a prospective study.
Article in European journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Nicotine Therapy for Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials.Biomedicines · 2025Article
- Personality traits and their effects in patients with hemifacial spasm.Scientific reports · 2025Article
- Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis.Hereditas · 2025Article
- Identifying modifiable factors associated with neuroimaging markers of brain health.CNS neuroscience & therapeutics · 2024Article
- Association of Personality Traits with Life and Work of Medical Students: An Integrative Review.International journal of environmental research and public health · 2022Review
- Mechanistic insights into the pathogenesis of neurodegenerative diseases: towards the development of effective therapy.Molecular and cellular biochemistry · 2021Review
- Neuroticism, Smoking, and the Risk of Parkinson's Disease.Journal of Parkinson's disease · 2021Article
- Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases.JAMA neurology · 2020Article
- Exploring causality of the association between smoking and Parkinson's disease.International journal of epidemiology · 2019Article
- A Novel Approach for Investigating Parkinson's Disease Personality and Its Association With Clinical and Psychological Aspects.Frontiers in psychology · 2019Article
- The Parkinson's phenome-traits associated with Parkinson's disease in a broadly phenotyped cohort.NPJ Parkinson's disease · 2019Article
- Occupational stress and risk for Parkinson's disease: A nationwide cohort study.Movement disorders : official journal of the Movement Disorder Society · 2018Article
- Reduced workforce participation 5 years prior to first Parkinson's disease sick-leave.NPJ Parkinson's disease · 2018Article
- The Rotterdam Study: 2018 update on objectives, design and main results.European journal of epidemiology · 2017Article
- Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder.Parkinsonism & related disorders · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
In this study, we explored the association between the personality traits, neuroticism and introversion, and risk of Parkinson disease (PD). A population-based cohort study was conducted using questionnaire data from the Swedish Twin Registry for twins born 1926-1958 (n > 29,000). Personality traits were assessed in 1973 by a short form of Eysenck's Personality Inventory. The cohort was followed from 1974 to 2012 through Swedish patient and cause of death registers for PD ascertainment. Cox proportional hazards regression was used to estimate subsequent risk of PD, adjusting for attained age, sex and smoking. A mediation analysis was performed to further explore the role of smoking in the relationship between personality trait and PD. Confounding by familial factors was explored using a within-pair analysis. During a mean follow-up time of 36.8 years, 197 incident PD cases were identified. Both neuroticism and introversion were associated with an increased risk of PD after adjustment. Smoking was a significant mediator in the relationship between personality traits and PD that partly accounted for the effect of introversion, whereas it acted as a suppressor for the effect of neuroticism on PD risk. In the within-pair analyses, associations for neuroticism and introversion were attenuated. In conclusion, our study provides evidence that neuroticism is associated with an increased risk of PD that is in part suppressed by smoking. There was a weak association between introversion and PD and this effect was at least partly mediated through smoking. The observed effects may partly be explained by familial factors shared by twins.
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Registered trials
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