Evidence map›Paper›PMID 26130060›Full record

ArticleExperimental gerontology2015

Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations--The LIFE Study.

Robert T Mankowski, Mylene Aubertin-Leheudre, Daniel P Beavers, Anda Botoseneanu, Thomas W Buford, Timothy Church, Nancy W Glynn, Abby C King, Christine Liu, Todd M Manini and 7 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Experimental gerontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05732935 (Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05732935 nacompletednot on this mapstarted 2023, after this paper: background citation

Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled45ConditionsOverweight and Obesity, Time Restricted Feeding, Alzheimer DiseaseArmsTime Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Robert T MankowskiDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA; Department of Rehabilitation Medicine, Erasmus University Medical Centre, Rotterdam 3000CA, The Netherlands.
Mylene Aubertin-LeheudreDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA; Department of Kinanthropology, University of Quebec, Montreal, Quebec H2X1Y4, Canada.
Daniel P BeaversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Anda BotoseneanuDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Thomas W BufordDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA.
Timothy ChurchPreventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Nancy W GlynnDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Abby C KingStanford Prevention Research Center, Department of Medicine, Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christine LiuDepartment of Medicine Geriatrics, Boston University School of Medicine, Boston, MA 02118, USA.
Todd M ManiniDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA.
Anthony P MarshDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA.
Mary McDermottDepartment of Internal Medicine, Northwestern Medical Faculty Foundation, Chicago, IL 60611, USA.
Joe R NoceraDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Marco PahorDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA.
Elsa S StrotmeyerDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15213, USA.
Stephen D AntonDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA. Electronic address: santon@ufl.edu.
LIFE Research Group

Funding

UF FIELD CENTERU01AG022376 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PAHOR, MARCO · 2003 to 2015
$83.3M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Intramural NIH HHSNCATS NIH HHS NIH/NCRR UL1TR000064NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIA NIH HHS 3U01AG022376NIA NIH HHS NIH/NIA P30AG028740NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG028740NIA NIH HHS U01 AG022376NIA NIH HHS U01AG22376
6 · The paper itself

Abstract

backgroundEpidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults.

methodsThe association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7 ± 5.3 years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI.

resultsParticipants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile.

conclusionsSedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.

Indexed as

Mobility LimitationSedentary BehaviorAccelerometryAgedAged, 80 and overCholesterol, HDLFemaleGeriatric AssessmentHumansMaleMetabolic SyndromeMotor ActivityRisk FactorsTime FactorsWaist CircumferenceCholesterol, HDLAccelerometryAgingDisabilityGlucoseWaist circumference

Identifiers

PMID26130060
PMCPMC4600654

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.