ArticleEndocrine2016
Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins.
Article in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults.Nutrients · 2019Trial
- Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Evaluating the influence of vitamin K supplementation on bone markers in hemodialysis patients.Annals of medicine and surgery (2012) · 2025Article
- Rationale and Protocol of the ETERNITY-ITA Study: Use of Etelcalcetide for Preserving Vitamin K-Dependent Protein Activity-An Italian Study.Journal of clinical medicine · 2024Article
- The Role of Vitamin K in CKD-MBD.Current osteoporosis reports · 2022Review
- Vitamin KOpen heart · 2021Review
- Vitamin K in CKD Bone Disorders.Calcified tissue international · 2021Review
- Vitamin K and Kidney Transplantation.Nutrients · 2020Review
- The Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease.International journal of molecular sciences · 2020Article
- Current Therapy in CKD Patients Can Affect Vitamin K Status.Nutrients · 2020Review
- Vitamin K effects in human health: new insights beyond bone and cardiovascular health.Journal of nephrology · 2020Review
- Effects of lanthanum carbonate on bone markers and bone mineral density in incident hemodialysis patients.Journal of bone and mineral metabolism · 2019Article
- Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus.Journal of nephrology · 2019Article
- Vitamin K in Chronic Kidney Disease.Nutrients · 2019Review
- Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification.Nutrients · 2019Review
- Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System.Frontiers in neuroscience · 2019Review
- Article
- Chronic kidney disease and fragility fracture.Clinical and experimental nephrology · 2017Review
- The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review.International journal of endocrinology · 2017Review
- Editorial comment on Vitamin K and vascular calcification in chronic kidney disease: An update of current evidence - The role of Vitamin K in managing chronic kidney disease-mineral bone disorder.Tzu chi medical journalArticle
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix Gla protein (MGP) and bone Gla protein (BGP) are two vitamin K-dependent proteins (VKDPs) involved in the regulation of vascular calcification (VC). We carried out a secondary analysis of the VIKI study to evaluate associations between drug consumption and VKDP levels in 387 hemodialyzed patients. The VIKI study assessed the prevalence of vitamin K deficiency in hemodialysis patients. We evaluated drug consumption, determined BGP and MGP levels, and verified the presence of any vertebral fractures (VF) and VC by spine radiographs. Total BGP levels were twice as high with calcimimetics versus no calcimimetics (290 vs. 158.5 mcg/L, p < 0.0001) and 69 % higher with vitamin D analogs (268 vs. 159 mcg/L, p < 0.0001). Total MGP was 19 % higher with calcimimetics (21.5 vs. 18.1 mcg/L, p = 0.04) and 54 % higher with calcium acetate (27.9 vs. 18.1 mcg/L, p = 0.003); no difference was found with vitamin D analogs (21.1 vs. 18.3 mcg/L, p = 0.43). Median Total BGP level was 29 % lower in patients with ≥1 VF (151 vs. 213 mcg/L, p = 0.0091) and 36 % lower in patients with VC (164 vs. 262.1 mcg/L, p = 0.0003). In non-survivors, median BGP and MGP were lower, but only for MGP this difference reached the statistical significance (152 vs. 191 mcg/L, p = 0.20 and 15.0 vs. 19.7 mcg/L, p = 0.02, respectively). Pending studies on vitamin K supplementation, calcimimetics, and vitamin D analogs may play a role in preserving vitamin K-dependent protein activity, thus contributing to bone and vascular health in CKD patients.
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