Evidence map›Paper›PMID 26130026›Full record

ArticlePediatric pulmonology2016

Increased circulating fibrocytes are associated with higher reticulocyte percent in children with sickle cell anemia.

Matthew S Karafin, Shibani Dogra, Mark Rodeghier, Marie Burdick, Borna Mehrad, C Edward Rose, Robert M Strieter, Michael R DeBaun, Robert C Strunk, Joshua J Field

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Matthew S KarafinMedical Sciences Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin.
Shibani DograDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Mark RodeghierIndependent Statistician, Chicago, Illinois.
Marie BurdickDepartment of Medicine, University of Virginia, Charlottesville, Virginia.
Borna MehradDepartment of Medicine, University of Virginia, Charlottesville, Virginia.
C Edward RoseDepartment of Medicine, University of Virginia, Charlottesville, Virginia.
Robert M StrieterNovartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Michael R DeBaunUniversity School of Medicine and Monroe Carell Jr Children's Hospital, Nashville, Tennessee.
Robert C StrunkDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Joshua J FieldMedical Sciences Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin.
Medical College of Wisconsin · USUniversity of Virginia · USBoston Biomedical Research Institute · USMonroe Carell Jr. Children's Hospital · USStatisticon (Sweden) · SEWashington University in St. Louis · US

Funding

Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia IIR01HL079937 · NHLBI · WASHINGTON UNIVERSITY · PI DEBAUN, MICHAEL R., STRUNK, ROBERT · 2005 to 2013
$10.4M
Fibrocytes in human pulmonary fibrosisR01HL098329 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA, ROSE, C EDWARD · 2011 to 2015
$2.7M
Fibrocytes in the Pathogenesis of Sickle Cell Lung DiseaseR01HL098526 · NHLBI · UNIVERSITY OF VIRGINIA · PI ROSE, C EDWARD · 2010 to 2013
$2.0M
NHLBI NIH HHS R01 HL079937NHLBI NIH HHS R01 HL098329NHLBI NIH HHS R01 HL098526
6 · The paper itself

Abstract

backgroundInterstitial lung disease is common in patients with sickle cell anemia (SCA). Fibrocytes are circulating cells implicated in the pathogenesis of pulmonary fibrosis and airway remodeling in asthma. In this study, we tested the hypotheses that fibrocyte levels are: (1) increased in children with SCA compared to healthy controls, and (2) associated with pulmonary disease. PROCEDURE: Cross-sectional cohort study of children with SCA who participated in the Sleep Asthma Cohort Study.

resultsFibrocyte levels were obtained from 45 children with SCA and 24 controls. Mean age of SCA cases was 14 years and 53% were female. In children with SCA, levels of circulating fibrocytes were greater than controls (P < 0.01). The fibrocytes expressed a hierarchy of chemokine receptors, with CXCR4 expressed on the majority of cells and CCR2 and CCR7 expressed on a smaller subset. Almost half of fibrocytes demonstrated α-smooth muscle actin activation. Increased fibrocyte levels were associated with a higher reticulocyte count (P = 0.03) and older age (P = 0.048) in children with SCA. However, children with increased levels of fibrocytes were not more likely to have asthma or lower percent predicted forced expiratory volume in 1 sec/forced vital capacity (FEV1 /FVC) or FEV1 than those with lower fibrocyte levels.

conclusionsHigher levels of fibrocytes in children with SCA compared to controls may be due to hemolysis. Longitudinal studies may be able to better assess the relationship between fibrocyte level and pulmonary dysfunction.

Indexed as

ReticulocytesAdolescentAnemia, Sickle CellAsthmaChildChild, PreschoolCohort StudiesCross-Sectional StudiesFemaleForced Expiratory VolumeHumansLung Diseases, InterstitialMalePulmonary FibrosisYoung Adultasthmafibrocytessickle cell anemia

Identifiers

PMID26130026
PMCPMC5559871
OpenAlexW2160793025

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.