ArticleGut2016
Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours.
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Article in Gut, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
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79citing papers in PubMed, 3 pooled it
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Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Association between the PSCA rs2976392 polymorphism and susceptibility to gastric cancer: a meta-analysis.Frontiers in genetics · 2025Pooled it
- Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development.Frontiers in genetics · 2022Pooled it
- Pooled it
- Genome wide association analysis and association of genetic risk and lifestyle with upper gastrointestinal cancer among an endoscopy-screened cohort in China.Science bulletin · 2026Article
- Multitrait GWAS and functional validation reveal genetic loci for gastric cancer.Nature communications · 2026Article
- Gastric cancer in China: Epidemiology, risk factors, and screening.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- The Role of MUC1 in Gastric Cancer Development.Cancers · 2025Review
- Poorer prognosis of early gastric cardia cancer compared to early gastric non-cardia cancer: evidence from SEER database analysis.Journal of gastrointestinal oncology · 2025Article
- Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.Cell reports. Medicine · 2025Article
- An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling.The Journal of clinical investigation · 2025Article
- Single-cell eQTL mapping reveals cell-type-specific genes associated with the risk of gastric cancer.Cell genomics · 2025Article
- The risk and distribution of second primary cancers according to subsite of primary stomach cancer: a retrospective cohort population-based study.Annals of medicine and surgery (2012) · 2024Article
- BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial-mesenchymal transition process.Cancer science · 2024Article
- Developing a prognostic signature: identifying differentially expressed genes in cardia and non-cardia gastric cancer for immunity and therapeutic sensitivity analysis.Journal of gastrointestinal oncology · 2024Article
- HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer.Cancer research · 2024Article
- Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Helicobacter pylori Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer.JAMA network open · 2024Article
- Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction.Frontiers in immunology · 2024Article
- The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer.Oncogene · 2023Article
- Design and quality control of large-scale two-sample Mendelian randomization studies.International journal of epidemiology · 2023Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
41 authors at 16 institutions in 4 countries.
Nan HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Xin SongHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Lixuan WeiDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Byung Sik KimDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jiwon BaekDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, South Korea.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland, USA.
Jiang ChangDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Charles ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland, USA.
Sanford M DawseyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Ti DingShanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China.
Yu-Tang GaoShanghai Cancer Institute, Shanghai, People's Republic of China.
Carol GiffenInformation Management Services Inc., Silver Spring, Maryland, USA.
Yaling HanDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Myunghee HongDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, South Korea.
Jia HuangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Hee Sung KimDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Woon-Puay KohDuke-NUS Graduate Medical School Singapore, Singapore, Singapore.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Yi Min MaoHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
You-Lin QiaoDepartment of Epidemiology, Cancer Institute and Hospital Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Xiao-Ou ShuDepartment of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
Wen TanDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Chaoyu WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chen WuDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Min-Jie WuCancer Research Center, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Yong-Bing XiangShanghai Cancer Institute, Shanghai, People's Republic of China.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland, USA.
Jeong Hwan YookDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jian-Min YuanUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Peng ZhangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Xue-Ke ZhaoHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Wei ZhengDepartment of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
Kyuyoung SongDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, South Korea.
Li-Dong WangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Dongxin LinDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USChinese Academy of Medical Sciences & Peking Union Medical College · CNZhengzhou University · CNAsan Medical Center · KRDivision of Cancer Epidemiology and GeneticsNational Cancer Institute · USShanghai Cancer Institute · CNUlsan College · KRUniversity of Ulsan · KRVanderbilt University · USDuke-NUS Medical School · SGInformation Management Services · USScience Applications International Corporation (United States) · USShanxi Provincial Cancer Hospital · CNUPMC Hillman Cancer Center · USXinxiang Medical University · CN
Funding
Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6MProspective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0MCohort Study of Cancer inhibitory Factors in MenR01CA082729 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2011
$6.3MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MTHE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3MShanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MCANCER RISK REDUCTION AND DIET--A COHORT STUDY OF WOMENR01CA070867 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 1996 to 2007
$4.6MCancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3MUpper Gastrointestinal Cancer StudiesZ01CP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI DAWSEY, SANFORD M · 2005 to 2008
$1.4MIntramural NIH HHS Z01 CP000185NCI NIH HHS R01 CA070867NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA082729NCI NIH HHS R01 CA144034NCI NIH HHS R37 CA070867NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182876NCI NIH HHS UM1 CA182910
Abstract
objectiveGenome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the gastric cardia versus the non-cardia.
designHere we present results for a GWAS using 2350 East Asian gastric cancer cases divided as 1189 gastric cardia and 1027 gastric non-cardia cases and 2708 controls. We also included up to 3042 cardia cases, 4359 non-cardia cases and 7548 controls for replication from two Chinese studies and one Korean study. From the GWAS, we selected 12 top SNPs for each gastric cancer subtype, 4 top SNPs for total gastric cancer and 1 SNP in MUC1 for replication testing.
resultsWe observed genome-wide significant associations for rs10074991 in PRKAA1 at 5p13.1 for cardia (p=7.36×10(-12)) and non-cardia cancers (p=2.42×10(-23)) with per allele OR (95% CI) for the combined endpoint of 0.80 (0.77 to 0.83). At 6p21.1, rs2294693 near UNC5CL was significantly associated with gastric non-cardia cancer risk (p=2.50×10(-8)), with OR (95% CI) of 1.18 (1.12 to 1.26), but there was only a nominal association for cardia cancer (p=1.47×10(-2)). We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers. Three SNPs in PSCA previously reported to be associated with gastric non-cardia cancer showed no apparent association for cardia cancer.
conclusionsOur results suggest that associations for SNPs with gastric cancer show some different results by tumour location in the stomach.
Indexed as
AdenocarcinomaCardiaStomach NeoplasmsAMP-Activated Protein KinasesAsian PeopleCase-Control StudiesChinaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracellular Signaling Peptides and ProteinsMaleMucin-1Polymorphism, Single NucleotideRepublic of KoreaAMP-Activated Protein KinasesIntracellular Signaling Peptides and ProteinsMUC1 protein, humanMucin-1PRKAA1 protein, humanUNC5CL protein, human
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