ArticleScientific reports2015
Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Parasitisterols A-C, 24,25-Dihydroxycholestane-Type Triterpenoids, from Oomycete Fish PathogenACS omega · 2026Article
- Catalytic and structural comparisons of linoleate dioxygenases and their cytochrome P450 companions with enzymes of the cyclooxygenase cascade.The Journal of biological chemistry · 2026Review
- Genome-wide identification and expression profile ofFrontiers in plant science · 2026Article
- Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes.Microbiome · 2025Article
- Metabolic Targets in CRC: The Emerging Role of Cytochrome P450 Inhibitors.Current pharmaceutical design · 2025Review
- Comprehensive Review on Plant Cytochrome P450 Evolution: Copy Number, Diversity, and Motif Analysis From Chlorophyta to Dicotyledoneae.Genome biology and evolution · 2024Review
- Robust Profiling of Cytochrome P450s (P450ome) in NotableLife (Basel, Switzerland) · 2022Article
- Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1.European journal of drug metabolism and pharmacokinetics · 2021Article
- In Silico Analysis of P450s and Their Role in Secondary Metabolism in the Bacterial ClassMolecules (Basel, Switzerland) · 2021Article
- An overview of the factors playing a role in cytochrome P450 monooxygenase and ferredoxin interactions.Biophysical reviews · 2020Review
- Impact of lifestyle on cytochrome P450 monooxygenase repertoire is clearly evident in the bacterial phylum Firmicutes.Scientific reports · 2020Article
- Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 inInternational journal of molecular sciences · 2020Article
- More P450s Are Involved in Secondary Metabolite Biosynthesis inInternational journal of molecular sciences · 2020Article
- Comparative Sequence Analysis ofToxins · 2019Article
- Distribution and Diversity of Cytochrome P450 Monooxygenases in the Fungal ClassInternational journal of molecular sciences · 2019Article
- Cytochrome P450 Monooxygenase CYP139 Family Involved in the Synthesis of Secondary Metabolites in 824 Mycobacterial Species.International journal of molecular sciences · 2019Article
- Similarities, variations, and evolution of cytochrome P450s in Streptomyces versus Mycobacterium.Scientific reports · 2019Article
- Article
- Comparative Analyses of Cytochrome P450s and Those Associated with Secondary Metabolism inInternational journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred and fifty-six P450s were found in oomycetes. These P450s were grouped into 15 P450 families and 84 P450 subfamilies. Among these, nine P450 families and 31 P450 subfamilies were newly found in oomycetes. Research revealed that oomycetes belonging to different orders contain distinct P450 families and subfamilies in their genomes. Evolutionary analysis and sequence homology data revealed P450 family blooms in oomycetes. Tandem arrangement of a large number of P450s belonging to the same family indicated that P450 family blooming is possibly due to its members' duplications. A unique combination of amino acid patterns was observed at EXXR and CXG motifs for the P450 families CYP5014, CYP5015 and CYP5017. A novel P450 fusion protein (CYP5619 family) with an N-terminal P450 domain fused to a heme peroxidase/dioxygenase domain was discovered in Saprolegnia declina. Oomycete P450 patterns suggested host influence in shaping their P450 content. This manuscript serves as reference for future P450 annotations in newly explored oomycetes.
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