ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
- Demand for heroin in rats: effects of non-drug alternative substitutes and complements.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- A Review of Behavioral Economic Manipulations Affecting Drug versus Nondrug Choice in Rats.Perspectives on behavior science · 2025Review
- More than just a prime: Cocaine gives monkeys the munchies.The Journal of pharmacology and experimental therapeutics · 2025Article
- Time to choose: impact of intertrial interval on selecting between methamphetamine and food reinforcement in male and female rats.Psychopharmacology · 2025Article
- Validation of drug-nondrug choice procedure to model maladaptive behavioural allocation to opioid use in rats.Addiction biology · 2024Article
- Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need.Science (New York, N.Y.) · 2024Article
- Cocaine and heroin interact differently with nondrug reinforcers in a choice situation.Experimental and clinical psychopharmacology · 2024Article
- The complexity of drug choice: rats prefer alcohol over social interaction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Rats choose alcohol over social reward in an operant choice procedure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse.Psychopharmacology · 2022Article
- Sensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations.Pharmacology, biochemistry, and behavior · 2022Article
- Effects of environmental manipulations on cocaine-vs-social choice in male and female rats.Pharmacology, biochemistry, and behavior · 2022Article
- From concepts to treatment: a dialog between a preclinical researcher and a clinician in addiction medicine.Translational psychiatry · 2022Review
- Choosing between cocaine and sucrose under the influence: testing the effect of cocaine tolerance.Psychopharmacology · 2022Article
- Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats.Psychopharmacology · 2021Article
- Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.Behavioural brain research · 2021Review
- Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats.eLife · 2021Article
- A drug-vs-food "choice" self-administration procedure in rats to investigate pharmacological and environmental mechanisms of substance use disorders.Journal of neuroscience methods · 2021Article
- The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.Behavioural brain research · 2021Article
- Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ample evidence shows that the setting can control drug choices in both humans and animals. Here we reveal in rats that a major mechanism of this control involves a regulation of the drug influence on other competing options at the time of choice. Briefly, rats were offered a choice between a drug dose (cocaine or heroin) and a brief access to water sweetened with saccharin in two different settings. In one setting, choosing under the influence was not possible and rats largely preferred saccharin over either cocaine or heroin. In contrast, when the same rats were shifted to a setting where choosing under the influence was possible, they chose the drug either nonexclusively or exclusively depending on whether the drug enhanced or suppressed sweet reward, respectively. Thus, when rats were under the orexigenic influence of heroin at the time of choice, they more frequently chose saccharin in alternation with heroin. In contrast, when rats were under the anorexic influence of cocaine, they stopped choosing saccharin and continued taking cocaine exclusively. These setting- and drug-specific changes in preference were rapid and reversible, and could be induced by passively administering cocaine or heroin before choice. Finally, rats behaved as if they were oblivious to the drug influence on their choices. This behavior could explain why rats are vulnerable to harm themselves, sometimes to the point of death, in settings where choices are made under the drug influence, notably if this influence excludes other important options or, conversely, enhances harmful ones.
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