ArticleJournal of experimental & clinical cancer research : CR2015
Low expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients.
Article in Journal of experimental & clinical cancer research : CR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma.Medicine · 2017Pooled it
- Research progress on molecular biomarkers of acute myeloid leukemia.Frontiers in oncology · 2023Review
- The role of non-coding RNAs in chemotherapy for gastrointestinal cancers.Molecular therapy. Nucleic acids · 2021Review
- Increased Plasma Levels of lncRNAsCancers · 2021Article
- Article
- Circular RNA circFNDC3AL Upregulates BCL9 Expression to Promote Chicken Skeletal Muscle Satellite Cells Proliferation and Differentiation by Binding to miR-204.Frontiers in cell and developmental biology · 2021Article
- Identification of Acute Myeloid Leukemia Bone Marrow Circulating MicroRNAs.International journal of molecular sciences · 2020Article
- Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever.Archives of rheumatology · 2020Article
- Low serum miR-223 expression predicts poor outcome in patients with acute myeloid leukemia.Journal of clinical laboratory analysis · 2020Article
- Regulation of phagolysosomal activity by miR-204 critically influences structure and function of retinal pigment epithelium/retina.Human molecular genetics · 2019Article
- Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia.Journal of hematology & oncology · 2019Review
- An integrated analysis to predict micro-RNAs targeting both stemness and metastasis in breast cancer stem cells.Journal of cellular and molecular medicine · 2019Article
- MicroRNA-204 inhibits the proliferation, migration and invasion of human lung cancer cells by targeting PCNA-1 and inhibits tumor growth in vivo.International journal of molecular medicine · 2019Article
- Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia.BMC cancer · 2019Article
- Evaluation of plasma microRNA expressions in patients with juvenile idiopathic arthritis.Clinical rheumatology · 2018Article
- Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb.Journal of experimental & clinical cancer research : CR · 2018Article
- miR-204 enhances p27 mRNA stability by targeting Brd4 in head and neck squamous cell carcinoma.Oncology letters · 2018Article
- Systematic analysis of lncRNA-miRNA-mRNA competing endogenous RNA network identifies four-lncRNA signature as a prognostic biomarker for breast cancer.Journal of translational medicine · 2018Article
- Genetic variation of the gene coding for microRNA-204 (miR-204) is a risk factor in acute myeloid leukaemia.BMC cancer · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs, play an essential role in the development and progression of acute leukemia. The aim of the study was to evaluate miR-204 expression in patients with AML at diagnosis and after induction chemotherapy, in comparison to healthy controls. We also investigated, if miR-204 expression correlates with clinical features of AML patients.
methodsmiR-204 expression has been analyzed using RT-PCR in 95 bone marrow specimens from newly diagnosed AML patients in comparison to 20 healthy subject.
resultsWe showed down-regulated miR-204 expression in AML patients, which was associated with shorter patients' survival. Higher expression of miR-204 in patients after induction therapy was correlated with complete remission achieving.
conclusionsWe showed low miR-204 expression in AML and found it to be an independent prognostic factor in this patient population.
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