Evidence map›Paper›PMID 26126877›Full record

ReviewJournal of assisted reproduction and genetics2015

IVF for fertility preservation in breast cancer patients--efficacy and safety issues.

M Shapira, H Raanani, D Meirow

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Fertility preservation in patients withEcancermedicalscience · 2020
    Review
  10. Counseling young women with early breast cancer on fertility preservation.Journal of assisted reproduction and genetics · 2019
    Article
  11. Article
  12. Immature Oocyte for Fertility Preservation.Frontiers in endocrinology · 2019
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. [Fertility preservation in breast cancer patients by embryo cryopreservation after ovarian stimulation with letrozole and FSH].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M ShapiraIVF Unit, Division of Obstetrics and Gynecology, Fertility Preservation Center, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
H Raanani
D Meirow
Tel Aviv University · ILSheba Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPotential risks on future fertility have become a dominant issue in consultation and management of newly diagnosed young cancer patients. Several fertility preservation strategies are currently available. Of those, ovarian stimulation followed by IVF and embryo cryopreservation is the most established one and is especially applicable in reproductive aged breast cancer patients.

aimThe aim of this study is to provide a comprehensive review on ovarian stimulation and IVF for fertility preservation in newly diagnosed breast cancer patients.

methodsReview of relevant literature is available through PubMed and Google scholar.

resultsThe use of IVF for fertility preservation in breast cancer patients raises dilemmas regarding efficacy and safety of controlled ovarian stimulation. Among these are the suggested role of malignancy and BRCA mutation in reducing ovarian response to stimulation, strategies designated to protect against hyper-estrogenic state associated with stimulation (co-treatment with tamoxifen or letrozole), and possible adjustments to accommodate oncologic-related time constraints.

conclusionOvarian stimulation followed by IVF forms an important fertility preservation strategy for newly diagnosed young breast cancer patients, though live born rates following thawed embryo transfer in these patients are still lacking. Recent advances in controlled ovarian stimulation protocols provide practical options for some of the challenges that breast cancer patients present.

Indexed as

Breast NeoplasmsBRCA1 ProteinBRCA2 ProteinEstrogensFemaleFertility PreservationFertilization in VitroHumansInfertility, FemaleOocytesOvarian Hyperstimulation SyndromeOvaryOvulation InductionPregnancyTime FactorsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanEstrogens

Identifiers

PMID26126877
PMCPMC4554381
OpenAlexW776503986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.