ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Cerebrovascular reactivity differences in healthy cerebral gray and white matter.Magnetic resonance in medicine · 2025Article
- Abnormal spontaneous regional white-matter brain activity in patients with obsessive-compulsive disorder.Frontiers in psychology · 2025Article
- Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Variable Cerebral Blood Flow Responsiveness to Acute Hypoxic Hypoxia.bioRxiv : the preprint server for biology · 2024Article
- CONMR in biomedicine · 2024Article
- The contribution of the vascular architecture and cerebrovascular reactivity to the BOLD signal formation across cortical depth.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- CVRmap-a complete cerebrovascular reactivity mapping post-processing BIDS toolbox.Scientific reports · 2024Article
- Cerebrovascular Reactivity Following Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2024Article
- Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy.Biomedical optics express · 2023Article
- Review
- Can Alterations in Cerebrovascular COJournal of clinical medicine · 2023Article
- The many layers of BOLD. The effect of hypercapnic and hyperoxic stimuli on macro- and micro-vascular compartments quantified byJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Examining temporal features of BOLD-based cerebrovascular reactivity in clinical populations.Frontiers in neurology · 2023Article
- Using carpet plots to analyze blood transit times in the brain during hypercapnic challenge magnetic resonance imaging.Frontiers in physiology · 2023Article
- Sinusoidal COFrontiers in physiology · 2023Article
- Cerebrovascular reactivity measurements using 3T BOLD MRI and a fixed inhaled COFrontiers in physiology · 2023Article
- Assessment of cerebrovascular function in patients with sickle cell disease using transfer function analysis.Physiological reports · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We define cerebral vascular reactivity (CVR) as the ratio of the change in blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) signal (S) to an increase in blood partial pressure of CO2 (PCO2): % Δ S/Δ PCO2 mm Hg. Our aim was to further characterize CVR into dynamic and static components and then study 46 healthy subjects collated into a reference atlas and 20 patients with unilateral carotid artery stenosis. We applied an abrupt boxcar change in PCO2 and monitored S. We convolved the PCO2 with a set of first-order exponential functions whose time constant τ was increased in 2-second intervals between 2 and 100 seconds. The τ corresponding to the best fit between S and the convolved PCO2 was used to score the speed of response. Additionally, the slope of the regression between S and the convolved PCO2 represents the steady-state CVR (ssCVR). We found that both prolongations of τ and reductions in ssCVR (compared with the reference atlas) were associated with the reductions in CVR on the side of the lesion. τ and ssCVR are respectively the dynamic and static components of measured CVR.
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