Evidence map›Paper›PMID 26126749›Full record

ArticleJournal of autism and developmental disorders2015

Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects.

J Mick Tilford, Nalin Payakachat, Karen A Kuhlthau, Jeffrey M Pyne, Erica Kovacs, Jayne Bellando, D Keith Williams, Werner B F Brouwer, Richard E Frye

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

J Mick TilfordDepartment of Health Policy and Management, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. tilfordmickj@uams.edu.
Nalin PayakachatDivision of Pharmaceutical Evaluation and Policy, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Karen A KuhlthauDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Jeffrey M PyneCenter for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System and Psychiatric Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Erica KovacsDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Jayne BellandoDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
D Keith WilliamsDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Werner B F BrouwerDepartment of Health Policy and Management, Erasmus University, Rotterdam, The Netherlands.
Richard E FryeDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USCentral Arkansas Veterans Healthcare System · USColumbia University Irving Medical Center · USErasmus University Rotterdam · NLHarvard University · US

Funding

Measuring quality adjusted life years in children with autism spectrum disordersR01MH089466 · NIMH · UNIV OF ARKANSAS FOR MED SCIS · PI KUHLTHAU, KAREN A, TILFORD, JOHN M · 2009 to 2010
$976k
Mapping Clinical Outcomes to Preference-based Measures from the NDAR DatabaseR03MH102495 · NIMH · UNIV OF ARKANSAS FOR MED SCIS · PI PAYAKACHAT, NALIN · 2014 to 2015
$149k
NIMH NIH HHS R01 MH089466NIMH NIH HHS R01MH089466NIMH NIH HHS R03MH102495PHS HHS UA3MC11054
6 · The paper itself

Abstract

Sleep problems in children with autism spectrum disorders (ASD) are under-recognized and under-treated. Identifying treatment value accounting for health effects on family members (spillovers) could improve the perceived cost-effectiveness of interventions to improve child sleep habits. A prospective cohort study (N = 224) was conducted with registry and postal survey data completed by the primary caregiver. We calculated quality of life outcomes for the child and the primary caregiver associated with treatments to improve sleep in the child based on prior clinical trials. Predicted treatment effects for melatonin and behavioral interventions were similar in magnitude for the child and for the caregiver. Accounting for caregiver spillover effects associated with treatments for the child with ASD increases treatment benefits and improves cost-effectiveness profiles.

Indexed as

Behavior TherapyRegistriesAdultAutistic DisorderCaregiversChildCost-Benefit AnalysisCost of IllnessCross-Sectional StudiesFemaleHumansMaleMelatoninProspective StudiesQuality-Adjusted Life YearsQuality of LifeMelatoninAutism spectrum disorderCaregiver healthChild healthChild sleep habitsCost-effectiveness analysisQuality adjusted life year

Identifiers

PMID26126749
PMCPMC4609586
OpenAlexW765829402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.