ArticleCytopathology : official journal of the British Society for Clinical Cytology2016
Evaluating cytology for the detection of invasive cervical cancer.
Article in Cytopathology : official journal of the British Society for Clinical Cytology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- The effect of COVID-19 on the cervical screening programme within a Northern Irish Health and Social care trust.The Ulster medical journal · 2023Article
- Performance of Aptima HPV E6/E7 mRNA Test for Detection of Cervical Lesions in a Large Chinese Population.Iranian journal of public health · 2022Article
- The incidence of cervical cancer in women with postcoital bleeding and abnormal appearance of the cervix referred through the 2-week wait pathway in the United Kingdom: A retrospective cohort study.The journal of obstetrics and gynaecology research · 2022Article
- Circulating mitochondrial DNA as a biomarker for lung cancer screening.Translational lung cancer research · 2022Article
- Preventive Health Screening during the COVID-19 Pandemic: A Cross-Sectional Survey among 102,928 Internet Users in Poland.Journal of clinical medicine · 2022Article
- Classification of cervical biopsy free-text diagnoses through linear-classifier based natural language processing.Journal of pathology informatics · 2022Article
- Risk factors of cervical cancer after a negative cytological diagnosis in Polish cervical cancer screening programme.Cancer medicine · 2021Article
- Prevalence, Incidence, and Clearance of Human Papillomavirus Types Covered by Current Vaccines in Men With Human Immunodeficiency Virus in the SUN Study.The Journal of infectious diseases · 2020Article
- Article
- Outcomes in Women With Cytology Showing Atypical Squamous Cells of Undetermined Significance With vs Without Human Papillomavirus Testing.JAMA oncology · 2017Observational
- Cytology in the diagnosis of cervical cancer in symptomatic young women: a retrospective review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016Article
- Evaluating cytology for the detection of invasive cervical cancer.Cytopathology : official journal of the British Society for Clinical Cytology · 2016Article
- Performance characteristics of visualising the cervix in symptomatic young females: a review of primary care records in females with and without cervical cancer.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016Review
- Cervical cytology and the diagnosis of cervical cancer in older women.Journal of medical screening · 2015Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo assess the sensitivity, the number needed to screen (NNS) and the positive predictive value (PPV) of cervical cytology for the diagnosis of cancer by age in a screening population.
methodsA retrospective cohort of women with invasive cervical cancer nested within a census of cervical cytology. All (c. 8 million) women aged 20-64 years with cervical cytology (excluding tests after an earlier abnormality). From April 2007 to March 2010, 3372 women had cervical cancer diagnosed within 12 months of such cytology in England. The sensitivity of cervical cytology to cancer, NNS to detect one cancer and predictive values of cytology were calculated for various 'referral' thresholds. These were calculated for ages 20-24, 25-34, 35-49 and 50-64 years.
resultsThe sensitivity of at least moderate dyskaryosis [equivalent to a high-grade squamous intraepithelial lesion (HSIL) or worse] for cancer of 89.4% [95% confidence interval (CI) 88.3-90.4%] in women offered screening was independent of age. At all ages, women with borderline-early recall or mild dyskaryosis on cytology (equivalent to ASC-US and LSIL, respectively, in the Bethesda system) had a similar risk of cervical cancer to the risk in all women tested. The PPV of severe dyskaryosis/?invasive and ?glandular neoplasia cytology (equivalent to squamous cell carcinoma and adenocarcinoma/adenocarcinoma in situ, respectively, in the Bethesda System) were 34% and 12%, respectively; the PPV of severe dyskaryosis (HSIL: severe dysplasia) was 4%. The NNS was lowest when the incidence of cervical cancer was highest, at ages 25-39 years, but the proportion of those with abnormal cytology who have cancer was also lowest in younger women.
conclusionsThe PPV of at least severe dyskaryosis (HSIL: severe dysplasia) for cancer was 4-10% of women aged 25-64 years, justifying a 2-week referral to colposcopy and demonstrating the importance of failsafe monitoring for such patients. The sensitivity of cytology for cervical cancer was excellent across all age groups.
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