Evidence map›Paper›PMID 26126208›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Compensatory Increase in Ovarian Aromatase in Older Regularly Cycling Women.

N D Shaw, S S Srouji, C K Welt, K H Cox, J H Fox, J A Adams, P M Sluss, J E Hall

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

  1. Hormones and Aging: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

N D ShawReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
S S SroujiReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
C K WeltReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
K H CoxReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
J H FoxReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
J A AdamsReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
P M SlussReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
J E HallReproductive Endocrine Unit (N.D.S., S.S.S., C.K.W., K.H.C., J.A.A., P.M.S., J.E.H.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Division of Endocrinology (N.D.S.), Children's Hospital Boston, and Center for Infertility and Reproductive Surgery (S.S.S., J.H.F.), Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Massachusetts General Hospital · USBrigham and Women's Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
TRAINING PROGRAM IN REPRODUCTIVE &DEVELOPMENTAL BIOLOGYT32HD007396 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI CROWLEY, WILLIAM FRANCIS · 1991 to 2018
$2.5M
FSH, Estradiol and Inhibin in Female ReproductionR01HD042708 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 2002 to 2006
$1.7M
The interaction between sleep and reproductive hormone secretion during pubertyK23HD073304 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SHAW, NATALIE DARA · 2012 to 2015
$514k
NCRR NIH HHS M01 RR001066NCRR NIH HHS M01 RR01066NCRR NIH HHS UL1 RR025758NICHD NIH HHS K23 HD073304NICHD NIH HHS R01 HD042708NICHD NIH HHS R01HD 42708NICHD NIH HHS T32 HD007396
6 · The paper itself

Abstract

contextSerum estradiol (E2) levels are preserved in older reproductive-aged women with regular menstrual cycles despite declining ovarian function.

objectiveThe objective of the study was to determine whether increased granulosa cell aromatase expression and activity account for preservation of E2 levels in older, regularly cycling women.

designThe protocol included daily blood sampling and dominant follicle aspirations at an academic medical center during a natural menstrual cycle. SUBJECTS: Healthy, regularly cycling older (36-45 y; n = 13) and younger (22-34 y; n = 14) women participated in the study.

main outcome measuresHormone levels were measured in peripheral blood and follicular fluid aspirates and granulosa cell CYP19A1 (aromatase) and FSH-R mRNA expression were determined.

resultsOlder women had higher FSH levels than younger women during the early follicular phase with similar E2 but lower inhibin B and antimullerian hormone levels. Late follicular phase serum E2 did not differ between the two groups. Follicular fluid E2 [older (O) = 960.0 [interquartile range (IQR) 765.0-1419.0]; younger (Y) = 994.5 [647.3-1426.5] ng/mL, P = 1.0], estrone (O = 39.6 [29.5-54.1]; Y = 28.8 [22.5-42.1] ng/mL, P = 0.3), and the E2 to testosterone (T) ratio (O = 109.0 ± 41.9; Y = 83.0 ± 18.6, P = .50) were preserved in older women. Granulosa cell CYP19A1 expression was increased 3-fold in older compared with younger women (P < .001), with no difference in FSH-R expression.

conclusionsOvarian aromatase expression increases with age in regularly cycling women. Thus, up-regulation of aromatase activity appears to compensate for the known age-related decrease in granulosa cell number in the dominant follicle to maintain ovarian estrogen production in older premenopausal women.

Indexed as

AdultAgingAromataseEstradiolFemaleFollicle Stimulating HormoneFollicular FluidGranulosa CellsHumansInhibinsLuteinizing HormoneMenstrual CycleMiddle AgedOvarian FollicleOvaryReceptors, FSHAromataseEstradiolFollicle Stimulating Hormoneinhibin BInhibinsLuteinizing HormoneReceptors, FSHTestosterone

Identifiers

PMID26126208
PMCPMC4570155
OpenAlexW1927075115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.