ArticleThe ISME journal2015
Making pathogens sociable: the [corrected] emergence of high relatedness through limited host invasibility.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- When does antimicrobial resistance increase bacterial fitness? Effects of dosing, social interactions, and frequency dependence on the benefits of AmpCEvolution letters · 2024Article
- Selecting for infectivity across metapopulations can increase virulence in the social microbeEvolutionary applications · 2023Article
- Signatures of selection in core and accessory genomes indicate different ecological drivers of diversification among Bacillus cereus clades.Molecular ecology · 2022Article
- Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium.Nature communications · 2022Article
- Strong Environment-Genotype Interactions Determine the Fitness Costs of Antibiotic ResistanceAntimicrobial agents and chemotherapy · 2020Article
- Article
- Crystal toxins and the volunteer's dilemma in bacteria.Journal of evolutionary biology · 2019Article
- Limiting opportunities for cheating stabilizes virulence in insect parasitic nematodes.Evolutionary applications · 2016Article
- Biofilms facilitate cheating and social exploitation of β-lactam resistance inNPJ biofilms and microbiomesArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Cooperation depends upon high relatedness, the high genetic similarity of interacting partners relative to the wider population. For pathogenic bacteria, which show diverse cooperative traits, the population processes that determine relatedness are poorly understood. Here, we explore whether within-host dynamics can produce high relatedness in the insect pathogen Bacillus thuringiensis. We study the effects of host/pathogen interactions on relatedness via a model of host invasion and fit parameters to competition experiments with marked strains. We show that invasibility is a key parameter for determining relatedness and experimentally demonstrate the emergence of high relatedness from well-mixed inocula. We find that a single infection cycle results in a bottleneck with a similar level of relatedness to those previously reported in the field. The bottlenecks that are a product of widespread barriers to infection can therefore produce the population structure required for the evolution of cooperative virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.