ArticlePloS one2015
Maternal Exposure to Cadmium and Manganese Impairs Reproduction and Progeny Fitness in the Sea Urchin Paracentrotus lividus.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Transgenerational Impact of Environmental Change.Advances in experimental medicine and biology · 2026Review
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Effects of Tributyltin-Contaminated Aquatic Environments and Remediated Water on Early Development of Sea Urchin (Animals : an open access journal from MDPI · 2023Article
- Effects of cadmium exposure during the breeding period on development and reproductive functions in rare minnow (Frontiers in physiology · 2023Article
- An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility.International journal of environmental research and public health · 2022Review
- Reprotoxic Impact of Environment, Diet, and Behavior.International journal of environmental research and public health · 2022Review
- Ovothiol ensures the correct developmental programme of the sea urchinOpen biology · 2022Article
- Divalent metal transporter-related protein restricts animals to marine habitats.Communications biology · 2021Article
- Article
- Cadmium stress effects indicating marine pollution in different species of sea urchin employed as environmental bioindicators.Cell stress & chaperones · 2019Review
- Biotic and environmental stress induces nitration and changes in structure and function of the sea urchin major yolk protein toposome.Scientific reports · 2018Article
- Metallothionein Gene Family in the Sea Urchin Paracentrotus lividus: Gene Structure, Differential Expression and Phylogenetic Analysis.International journal of molecular sciences · 2017Article
- Marine Toxin Okadaic Acid Affects the Immune Function of Bay Scallop (Argopecten irradians).Molecules (Basel, Switzerland) · 2016Article
- Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms.Scientific reports · 2016Article
- Shedding light on ovothiol biosynthesis in marine metazoans.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal contamination represents one of the major sources of pollution in marine environments. In this study we investigated the short-term effects of ecologically relevant cadmium and manganese concentrations (10(-6) and 3.6 x 10(-5) M, respectively) on females of the sea urchin Paracentrotus lividus and their progeny, reared in the absence or presence of the metal. Cadmium is a well-known heavy metal, whereas manganese represents a potential emerging contaminant, resulting from an increased production of manganese-containing compounds. The effects of these agents were examined on both P. lividus adults and their offspring following reproductive state, morphology of embryos, nitric oxide (NO) production and differential gene expression. Here, we demonstrated that both metals differentially impaired the fertilization processes of the treated female sea urchins, causing modifications in the reproductive state and also affecting NO production in the ovaries. A detailed analysis of the progeny showed a high percentage of abnormal embryos, associated to an increase in the endogenous NO levels and variations in the transcriptional expression of several genes involved in stress response, skeletogenesis, detoxification, multi drug efflux processes and NO production. Moreover, we found significant differences in the progeny from females exposed to metals and reared in metal-containing sea water compared to embryos reared in non-contaminated sea water. Overall, these results greatly expanded previous studies on the toxic effects of metals on P. lividus and provided new insights into the molecular events induced in the progeny of sea urchins exposed to metals.
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