Evidence map›Paper›PMID 26125565›Full record

ArticlePloS one2015

Tooth Retrospective Dosimetry Using Electron Paramagnetic Resonance: Influence of Irradiated Dental Composites.

Céline M Desmet, Andrej Djurkin, Ana Maria Dos Santos-Goncalvez, Ruhong Dong, Maciej M Kmiec, Kyo Kobayashi, Kevin Rychert, Sébastien Beun, Julian G Leprince, Gaëtane Leloup and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Céline M DesmetBiomedical Magnetic Resonance Research group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Andrej DjurkinSchool of Dentistry and Stomatology, Université catholique de Louvain, Brussels, Belgium.
Ana Maria Dos Santos-GoncalvezAdvanced Drug Delivery and Biomaterials Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Ruhong DongEPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
Maciej M KmiecEPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
Kyo KobayashiEPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
Kevin RychertEPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
Sébastien BeunSchool of Dentistry and Stomatology, Université catholique de Louvain, Brussels, Belgium.
Julian G LeprinceAdvanced Drug Delivery and Biomaterials Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium; Center for Research and Engineering on Biomaterials CRIBIO, Université catholique de Louvain, Brussels, Belgium.
Gaëtane LeloupAdvanced Drug Delivery and Biomaterials Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium; Center for Research and Engineering on Biomaterials CRIBIO, Université catholique de Louvain, Brussels, Belgium.
Philippe LevêqueBiomedical Magnetic Resonance Research group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Bernard GallezBiomedical Magnetic Resonance Research group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium; Center for Research and Engineering on Biomaterials CRIBIO, Université catholique de Louvain, Brussels, Belgium.
UCLouvain · BEDartmouth College · US

Funding

Scientific and Administrative Core: Dartmouth Medical SchoolU19AI091173 · NIAID · DARTMOUTH COLLEGE · PI SWARTS, STEVEN GREGORY · 2010 to 2014
$16.3M
NIAID NIH HHS U19 AI091173NIAID NIH HHS U19AI091173
6 · The paper itself

Abstract

In the aftermath of a major radiological accident, the medical management of overexposed individuals will rely on the determination of the dose of ionizing radiations absorbed by the victims. Because people in the general population do not possess conventional dosimeters, after the fact dose reconstruction methods are needed. Free radicals are induced by radiations in the tooth enamel of victims, in direct proportion to dose, and can be quantified using Electron Paramagnetic Resonance (EPR) spectrometry, a technique that was demonstrated to be very appropriate for mass triage. The presence of dimethacrylate based restorations on teeth can interfere with the dosimetric signal from the enamel, as free radicals could also be induced in the various composites used. The aim of the present study was to screen irradiated composites for a possible radiation-induced EPR signal, to characterize it, and evaluate a possible interference with the dosimetric signal of the enamel. We investigated the most common commercial composites, and experimental compositions, for a possible class effect. The effect of the dose was studied between 10 Gy and 100 Gy using high sensitivity X-band spectrometer. The influence of this radiation-induced signal from the composite on the dosimetric signal of the enamel was also investigated using a clinical L-Band EPR spectrometer, specifically developed in the EPR center at Dartmouth College. In X-band, a radiation-induced signal was observed for high doses (25-100 Gy); it was rapidly decaying, and not detected after only 24 h post irradiation. At 10 Gy, the signal was in most cases not measurable in the commercial composites tested, with the exception of 3 composites showing a significant intensity. In L-band study, only one irradiated commercial composite influenced significantly the dosimetric signal of the tooth, with an overestimation about 30%. In conclusion, the presence of the radiation-induced signal from dental composites should not significantly influence the dosimetry for early dose assessment.

Indexed as

Composite ResinsDental EnamelElectron Spin Resonance SpectroscopyHumansMethacrylatesRadiation ExposureRadiotherapy Planning, Computer-AssistedComposite ResinsMethacrylates

Identifiers

PMID26125565
PMCPMC4488324
OpenAlexW1520697619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.