ArticlePloS one2015
Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- HECT ubiquitin ligases as regulators of inflammatory signalling.Cell death and differentiation · 2026Review
- aPKC and F-actin dynamics promote Hippo pathway polarity in asymmetrically dividing neuroblasts.Biology open · 2026Article
- The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair.Cell death discovery · 2025Review
- The epidermal growth factor receptor regulates YAP signalling and promotes diabetic retinal fibrosis by modulating the degradation of SAV1.Journal of translational medicine · 2025Article
- Small molecule induced STING degradation facilitated by the HECT ligase HERC4.Nature communications · 2024Article
- Cortical tension promotes Kibra degradation via Par-1.Molecular biology of the cell · 2024Article
- HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.The EMBO journal · 2023Article
- Article
- Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling.The Journal of biological chemistry · 2020Article
- E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation.Journal of molecular cell biology · 2019Article
- Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing.Molecular cell · 2018Article
- Activation mechanisms of the Hippo kinase signaling cascade.Bioscience reports · 2018Review
- Regulation of the Hippo signaling pathway by ubiquitin modification.BMB reports · 2018Review
- SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.eLife · 2017Article
- Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.eLife · 2017Article
- The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.PLoS genetics · 2016Article
- Functional and pathological relevance of HERC family proteins: a decade later.Cellular and molecular life sciences : CMLS · 2016Review
- Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.PLoS genetics · 2016Article
- Mechanisms of Hippo pathway regulation.Genes & development · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Signalling through the Hippo (Hpo) pathway involves a kinase cascade, which leads to the phosphorylation and inactivation of the pro-growth transcriptional co-activator Yorkie (Yki). Despite the identification of a large number of pathway members and modulators, our understanding of the molecular events that lead to activation of Hpo and the downstream kinase Warts (Wts) remain incomplete. Recently, targeted degradation of several Hpo pathway components has been demonstrated as a means of regulating pathway activity. In particular, the stability of scaffold protein Salvador (Sav), which is believed to promote Hpo/Wts association, is crucially dependent on its binding partner Hpo. In a cell-based RNAi screen for ubiquitin regulators involved in Sav stability, we identify the HECT domain protein Herc4 (HECT and RLD domain containing E3 ligase) as a Sav E3 ligase. Herc4 expression promotes Sav ubiquitylation and degradation, while Herc4 depletion stabilises Sav. Interestingly, Hpo reduces Sav/Herc4 interaction in a kinase-dependent manner. This suggests the existence of a positive feedback loop, where Hpo stabilises its own positive regulator by antagonising Herc4-mediated degradation of Sav.
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Registered trials
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