Evidence map›Paper›PMID 26125501›Full record

ArticleBiomaterials2015

Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras.

Anusuya Das, Claire E Segar, Yihsuan Chu, Tiffany W Wang, Yong Lin, Chunxi Yang, Xeujun Du, Roy C Ogle, Quanjun Cui, Edward A Botchwey

Open access · greenAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Anusuya DasDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Claire E SegarDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Yihsuan ChuDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Tiffany W WangDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Yong LinDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Chunxi YangDepartment of Orthopaedic Surgery, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Xeujun DuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China.
Roy C OgleSchool of Medical Diagnostic and Translational Sciences, Old Dominion University, Norfolk, VA, USA.
Quanjun CuiDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Edward A BotchweyDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. Electronic address: Edward.botchwey@bme.gatech.edu.
Georgia Institute of Technology · USUniversity of Virginia · USFirst Affiliated Hospital of Xinxiang Medical University · CNOld Dominion University · USShanghai Tenth People's Hospital · CN

Funding

Phospholipid Growth Factors for Therapeutic Arteriogenesis and Tissue EngineeringR01AR056445 · NIAMS · UNIVERSITY OF VIRGINIA · PI BOTCHWEY, EDWARD A. · 2009 to 2014
$1.8M
Therapeutic S1P Drug Targets for Cranial Bone RepairR01DE019935 · NIDCR · UNIVERSITY OF VIRGINIA · PI BOTCHWEY, EDWARD A. · 2009 to 2013
$1.8M
NIAMS NIH HHS R01 AR056445NIAMS NIH HHS R01AR056445-01A2NIDCR NIH HHS R01 DE019935NIDCR NIH HHS R01DE019935-01
6 · The paper itself

Abstract

Bone grafting procedures are performed to treat wounds incurred during wartime trauma, accidents, and tumor resections. Endogenous mechanisms of repair are often insufficient to ensure integration between host and donor bone and subsequent restoration of function. We investigated the role that bone marrow-derived cells play in bone regeneration and sought to increase their contributions by functionalizing bone allografts with bioactive lipid coatings. Polymer-coated allografts were used to locally deliver the immunomodulatory small molecule FTY720 in tibial defects created in rat bone marrow chimeras containing genetically-labeled bone marrow for monitoring cell origin and fate. Donor bone marrow contributed significantly to both myeloid and osteogenic cells in remodeling tissue surrounding allografts. FTY720 coatings altered the phenotype of immune cells two weeks post-injury, which was associated with increased vascularization and bone formation surrounding allografts. Consequently, degradable polymer coating strategies that deliver small molecule growth factors such as FTY720 represent a novel therapeutic strategy for harnessing endogenous bone marrow-derived progenitors and enhancing healing in load-bearing bone defects.

Indexed as

Bone TransplantationAllograftsAnimalsBone and BonesBone Marrow CellsCell LineageDrug CarriersDrug Delivery SystemsFemaleFingolimod HydrochlorideGenes, ReporterGreen Fluorescent ProteinsImmunologic FactorsLactic AcidMaleMyelopoiesisDrug Carriersenhanced green fluorescent proteinFingolimod HydrochlorideGreen Fluorescent ProteinsImmunologic FactorsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerBone graftBone marrowImmunomodulationPhospholipidProgenitor cells

Identifiers

PMID26125501
PMCPMC4551493
OpenAlexW586811056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.