Evidence map›Paper›PMID 26125020›Full record

ArticleFrontiers in bioengineering and biotechnology2015

MetabNet: An R Package for Metabolic Association Analysis of High-Resolution Metabolomics Data.

Karan Uppal, Quinlyn A Soltow, Daniel E L Promislow, Lynn M Wachtman, Arshed Ali Quyyumi, Dean P Jones

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery.Metabolomics : Official journal of the Metabolomic Society · 2022
    Review
  5. Review
  6. Article
  7. Article
  8. Omics Integration for Mitochondria Systems Biology.Antioxidants & redox signaling · 2020
    Review
  9. Review
  10. Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study.Metabolomics : Official journal of the Metabolomic Society · 2019
    Article
  11. Metabolomic assessment of exposure to near-highway ultrafine particles.Journal of exposure science & environmental epidemiology · 2019
    Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Review
  17. Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Karan UppalDivision of Pulmonary Medicine, Department of Medicine, Emory University , Atlanta, GA , USA.
Quinlyn A SoltowDivision of Pulmonary Medicine, Department of Medicine, Emory University , Atlanta, GA , USA.
Daniel E L PromislowDepartment of Pathology, University of Washington , Seattle, WA , USA.
Lynn M WachtmanNew England Primate Research Center, Harvard University , Southborough, MA , USA.
Arshed Ali QuyyumiDivision of Cardiology, Department of Medicine, Emory University , Atlanta, GA , USA.
Dean P JonesDivision of Pulmonary Medicine, Department of Medicine, Emory University , Atlanta, GA , USA.
Emory University · USHarvard University · USUniversity of Washington · US

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Methods and Data CoreR24HD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI TOLNAY, STEWART E · 2002 to 2016
$9.3M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
Metabolomics of subclinical and clinical cardiovascular diseaseP20HL113451 · NHLBI · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2012 to 2016
$4.3M
A metabolomic model of aging in the common marmosetR01AG038746 · NIA · EMORY UNIVERSITY · PI JONES, DEAN PAUL, PROMISLOW, DANIEL EDWARD · 2010 to 2014
$2.5M
Orbitrap Elite/H-ESI BundleS10OD018006 · OD · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2014 to 2014
$600k
Mitochondria Environmental Stress Signaling NetworksR21ES025632 · NIEHS · EMORY UNIVERSITY · PI GO KANG, YOUNG-MI, JONES, DEAN PAUL · 2015 to 2017
$576k
NHLBI NIH HHS P20 HL113451NIAID NIH HHS HHSN272201200031CNIA NIH HHS R01 AG038746NICHD NIH HHS R24 HD042828NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R21 ES025632NIEHS NIH HHS T32 ES012870NIH HHS S10 OD018006
6 · The paper itself

Abstract

Liquid-chromatography high-resolution mass spectrometry provides capability to measure >40,000 ions derived from metabolites in biologic samples. This presents challenges to confirm identities of known chemicals and delineate potential metabolic pathway associations of unidentified chemicals. We provide an R package for metabolic network analysis, MetabNet, to perform targeted metabolome-wide association study of specific metabolites to facilitate detection of their related metabolic pathways and network structures.

Indexed as

cholinemetabolic networksmetabolic pathwaysmetabolite identificationmetabolomicstargeted MWAS

Identifiers

PMID26125020
PMCPMC4464066
OpenAlexW1537044725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.