ArticleAfrican health sciences2015
A non-specific biomarker of disease activity in HIV/AIDS patients from resource-limited environments.
Article in African health sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Emerging perovskite-based electrochemical biosensors for different biomarkers detection: innovations, applications, and future prospects.Mikrochimica acta · 2025Review
- Association between cytokine and increased risk of death in ART- naïve and ART-non-adherence patients hospitalized with advanced HIV disease.BMC infectious diseases · 2025Observational
- Cellular immunity in subacute thyroiditis: a new perspective through neopterin.Clinical and experimental immunology · 2022Article
- Cytokine profiles in highly active antiretroviral treatment non-adherent, adherent and naive HIV-1 infected patients in Western Kenya.African health sciences · 2021Article
- Metabolomics in infectious diseases and drug discovery.Molecular omics · 2021Review
- Comparison between plasma neopterin and the urine neopterin:creatinine ratio as inflammatory biomarkers.African health sciences · 2019Article
- Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients.Frontiers in cellular and infection microbiology · 2018Article
- Article
- Infectious diseases and chronic care in Africa.African health sciences · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA general non-specific marker of disease activity that could alert the clinician and prompt further investigation would be of value in patients with HIV/AIDS, especially in resource limited environments.
objectiveTo investigate the potential of neopterin as non-specific biomarker in patients with advanced HIV/AIDS.
methodsCross-sectional study in 105 HIV positive patients (75 on highly active antiretroviral treatment (HAART). Neopterin was assessed by enzyme linked immune-absorbent assay and cytokines by flow cytometry.
resultsNeopterin levels were significantly higher (p<0.001) for the total patient than for the control group. Significant correlations between neopterin and plasma indicators of inflammation showed neopterin to be a good indicator of active inflammatory status and of the effect of HAART on the immune system. Neopterin was superior to C-reactive protein and to individual cytokines as indicator of immune deficiency. Increased neopterin levels were associated with a decline in albumin, haemoglobin and the albumin/globulin ratio, and with increases in red cell distribution width.
conclusionsPlasma neopterin is a good non-specific biomarker of disease activity in HIV/AIDS patients. It is a good indicator of inflammatory activity, perpetuation of inflammation-associated co-morbidities, degree of immune deficiency and has predictive value for underlying disease, and for monitoring the HAART response.
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