ReviewFrontiers in systems neuroscience2015
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry.
Review in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
151 citing papers in PubMed, 3 syntheses or guidelines pooled it, 330 citations in OpenAlex.
- Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward.Reviews in endocrine & metabolic disorders · 2022Pooled it
- Impulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies.Progress in neuro-psychopharmacology & biological psychiatry · 2021Pooled it
- Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The EDC mixture "NeuroMix" alters neuroendocrine physiology, fatty food preference, and the central reward transcriptome.Endocrinology · 2026Article
- The Endogenous Opioid System in Compulsive Eating.Brain sciences · 2026Review
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Ventral pallidal GABAergic neurons control hedonic feeding and obesity.bioRxiv : the preprint server for biology · 2026Article
- The Neural Network of Orexin-A: Implications in Feeding Regulation and Obesity-Anxiety Comorbidity.Brain sciences · 2026Review
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Effects of prenatal methadone and buprenorphine exposure on motivated responding for sucrose and gene expression in adult male and female rats.Addiction neuroscience · 2026Article
- Lateral hypothalamic melanin concentrating hormone-expressing neurons both promote and are required for cue-potentiated feeding.Journal of neuroendocrinology · 2026Article
- Ventral Pallidum Cholinergic Neurons Respond to Reward and Signal Reward Value.bioRxiv : the preprint server for biology · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Activation of dopamine D4 receptors in the nucleus accumbens shell increases motivation for palatable food and homeostatic feeding, whereas systemic blockade reduces feeding behavior in rats.Frontiers in psychology · 2026Article
- Unravelling the obesity epidemic among young people in Qatar: a literature review.Frontiers in public health · 2026Review
- Long-term sugar consumption alters extracellular dopamine and acetylcholine levels in the nucleus accumbens shell.Frontiers in behavioral neuroscience · 2026Article
- New perspective on acupuncture treatment for obesity: mechanisms in the brain based on multidimensional neural circuits.American journal of translational research · 2026Review
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.bioRxiv : the preprint server for biology · 2025Article
91 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The study of the neural bases of eating behavior, hunger, and reward has consistently implicated the lateral hypothalamus (LH) and its interactions with mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus accumbens (NAc) and ventral pallidum (VP), in controlling motivation to eat. The NAc and VP play special roles in mediating the hedonic impact ("liking") and motivational incentive salience ("wanting") of food rewards, and their interactions with LH help permit regulatory hunger/satiety modulation of food motivation and reward. Here, we review some progress that has been made regarding this circuitry and its functions: the identification of localized anatomical hedonic hotspots within NAc and VP for enhancing hedonic impact; interactions of NAc/VP hedonic hotspots with specific LH signals such as orexin; an anterior-posterior gradient of sites in NAc shell for producing intense appetitive eating vs. intense fearful reactions; and anatomically distributed appetitive functions of dopamine and mu opioid signals in NAc shell and related structures. Such findings help improve our understanding of NAc, VP, and LH interactions in mediating affective and motivation functions, including "liking" and "wanting" for food rewards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.