ArticleInternational journal of chronic obstructive pulmonary disease2015
Severe hypoalbuminemia is a strong independent risk factor for acute respiratory failure in COPD: a nationwide cohort study.
Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 50 citations in OpenAlex.
- PhenoNMF: A novel multi-layer matrix factorization framework for age-stratified comprehensive phenotypic similarity analysis.BMC medical informatics and decision making · 2026Article
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- Serum Albumin is Linearly and Negatively Associated With the Risk of All-cause and Cardiovascular Death in Coronary Heart Disease Patients.Reviews in cardiovascular medicine · 2025Article
- The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007-2010.International journal of chronic obstructive pulmonary disease · 2025Article
- The red blood cell distribution width to albumin ratio was a potential prognostic biomarker for acute respiratory failure: a retrospective study.BMC medical informatics and decision making · 2024Article
- Association between protein intake, serum albumin and blood eosinophil in US asthmatic adults.Frontiers in immunology · 2024Article
- The importance of the erythrocyte distribution width/albumin ratio in patients with chronic obstructive pulmonary disease exacerbation.Saudi medical journal · 2024Article
- Relationship Between Systemic Immune-Inflammation Index and Risk of Respiratory Failure and Death in COPD: A Retrospective Cohort Study Based on the MIMIC-IV Database.International journal of chronic obstructive pulmonary disease · 2024Article
- A Low Eosinophil to Platelet Ratio as a Worse Prognostic Index for Emergency Department Attendance in Acute Exacerbation of COPD.International journal of chronic obstructive pulmonary disease · 2024Article
- Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2023Article
- The Relationship Between Prognostic Nutritional Indexes and the Clinical Outcomes of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Article
- Association of chronic kidney disease with perioperative outcomes following acute lower limb revascularization.Surgery open science · 2022Article
- A review on the Role of Oral Nutritional Supplements in Chronic Obstructive Pulmonary Disease.The journal of nutrition, health & aging · 2022Review
- Assessment of Risk Factors for Mortality in Patients in Medical Intensive Care Unit of a Tertiary Hospital.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Prognosis of hypoglycemia episode in cirrhotic patients during hospitalization.BMC gastroenterology · 2021Article
- Article
- Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- Study on effects of care bundles on patients with severe pneumonia complicated with respiratory failure.American journal of translational research · 2021Article
- Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.PloS one · 2021Article
- Preoperative malnutrition with mild hypoalbuminemia associated with postoperative mortality and morbidity of colorectal cancer: a propensity score matching study.Nutrition journal · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory failure (ARF) is a life-threatening event, which is frequently associated with the severe exacerbations of chronic obstructive pulmonary disease (COPD). Hypoalbuminemia is associated with increased mortality in patients with COPD. However, to date, little is known regarding whether or not hypoalbuminemia is a risk factor for developing ARF in COPD.
methodsWe conducted a retrospective cohort study using data from the National Health Insurance system of Taiwan. A total of 42,732 newly diagnosed COPD patients (age ≥40 years) from 1997 to 2011 were enrolled. Among them, 1,861 (4.36%) patients who had received albumin supplementation were defined as hypoalbuminemia, and 40,871 (95.6%) patients who had not received albumin supplementation were defined as no hypoalbuminemia.
resultsOf 42,732 newly diagnosed COPD patients, 5,248 patients (12.3%) developed ARF during the 6 years follow-up period. Patients with hypoalbuminemia were older, predominantly male, had more comorbidities, and required more steroid treatment and blood transfusions than patients without hypoalbuminemia. In a multivariable Cox regression analysis model, being elderly was the strongest independent risk factor for ARF (adjusted hazard ratio [HR]: 4.63, P<0.001), followed by hypoalbuminemia (adjusted HR: 2.87, P<0.001). However, as the annual average dose of albumin supplementation was higher than 13.8 g per year, the risk for ARF was the highest (adjusted HR: 11.13, 95% CI: 10.35-11.98, P<0.001).
conclusionHypoalbuminemia is a strong risk factor for ARF in patients with COPD. Therefore, further prospective studies are required to verify whether or not albumin supplementation or nutritional support may help to reduce the risk of ARF in patients with COPD.
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