Evidence map›Paper›PMID 26124326›Full record

ArticleAnticancer research2015

SPINK1 Promoter Variants Are Associated with Prostate Cancer Predisposing Alterations in Benign Prostatic Hyperplasia Patients.

Danyelle Winchester, Luisel Ricks-Santi, Tshela Mason, Muneer Abbas, Robert L Copeland, Desta Beyene, Emmanuel Y Jingwi, Georgia M Dunston, Yasmine M Kanaan

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Anticancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Danyelle WinchesterDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, U.S.A.
Luisel Ricks-SantiCancer Research Center, Hampton University, Hampton, VA, U.S.A.
Tshela MasonNational Human Genome Center, Howard University, Washington, DC, U.S.A.
Muneer AbbasNational Human Genome Center, Howard University, Washington, DC, U.S.A. Department of Microbiology, College of Medicine, Howard University, Washington, DC, U.S.A.
Robert L CopelandDepartment of Pharmacology, College of Medicine, Howard University, Washington, DC, U.S.A.
Desta BeyeneCancer Center, Howard University, Washington, DC, U.S.A.
Emmanuel Y JingwiCancer Center, Howard University, Washington, DC, U.S.A.
Georgia M DunstonNational Human Genome Center, Howard University, Washington, DC, U.S.A. Department of Microbiology, College of Medicine, Howard University, Washington, DC, U.S.A. Cancer Center, Howard University, Washington, DC, U.S.A.
Yasmine M KanaanDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, U.S.A. Cancer Center, Howard University, Washington, DC, U.S.A. ymkanaan@howard.edu.

Funding

STRUCTURAL/FUNCTIONAL CHARACTERIZATION OF AMINOGLYCOSIDEG12RR003048 · NCRR · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 1985 to 2011
$19.0M
The Howard University SCORE Program Supplemental GrantS06GM008016 · NIGMS · HOWARD UNIVERSITY · PI NELSON, KAREN ELIZABETH · 1989 to 2009
$16.1M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
INSTITUTIONAL RESEARCH CANCER EPIDEMIOLOGY FELLOWSHIPT32CA009314 · NCI · JOHNS HOPKINS UNIVERSITY · PI Corinne E. Joshu, Meghan Bridgid Moran · 1985 to 2026
$11.2M
NCI NIH HHS T32 CA009314NCRR NIH HHS G12 RR003048NIGMS NIH HHS S06 GM008016NIGMS NIH HHS S06GM08016NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

BACKGROUND/

aimSeveral studies reported that patients with benign prostatic hyperplasia (BPH) experienced a 10% increased incidence of prostate cancer (PCa) after the first 5 years of diagnosis. We investigated the association between single nucleotide polymorphisms (SNPs) in the promoter of Serine Protease Inhibitor Kazal Type 1 (SPINK1) and the increased risk of BPH and PCa. MATERIALS AND

methodsWe genotyped three SNPs in a cases-control study, including BPH and PCa cases. Multiple logistic regression models were applied to analyze clinical and genotypic data.

resultsWe found an inverse association between SNP rs10035432 and BPH under the log-additive (p=0.007) model. No association was found between these SNPs and PCa risk. However, we observed a possible association between rs1432982 and lower-grade PCa (p=0.05) under the recessive model.

conclusionSPINK1 promoter variants are likely to be associated with the risk of BPH.

Indexed as

Carrier ProteinsCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticProstate-Specific AntigenProstatic HyperplasiaProstatic NeoplasmsRiskTrypsin Inhibitor, Kazal PancreaticCarrier ProteinsProstate-Specific AntigenSPINK1 protein, humanTrypsin Inhibitor, Kazal PancreaticAfrican AmericanBPHGleasonprostate cancerSNPsSPINK1

Identifiers

PMID26124326
PMCPMC4545211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.