ArticleThe Journal of cell biology2015
A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Nuclear Dynamics in Quiescent Cells: Conserved Mechanisms from Yeasts to Mammals.Biomolecules · 2026Review
- A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit.eLife · 2024Article
- Cellular quiescence in budding yeast.Yeast (Chichester, England) · 2021Review
- Septins in Stem Cells.Frontiers in cell and developmental biology · 2021Review
- Reversible solidification of fission yeast cytoplasm after prolonged nutrient starvation.Journal of cell science · 2019Article
- Glucose starvation triggers filamentous septin assemblies in anBiology open · 2019Article
- Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate.eLife · 2018Article
- Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis.The Journal of cell biology · 2017Article
- Transcriptional reprogramming in cellular quiescence.RNA biology · 2017Review
- Microtubules are reversibly depolymerized in response to changing gaseous microenvironments withinMolecular biology of the cell · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Cells perpetually face the decision to proliferate or to stay quiescent. Here we show that upon quiescence establishment, Schizosaccharomyces pombe cells drastically rearrange both their actin and microtubule (MT) cytoskeletons and lose their polarity. Indeed, while polarity markers are lost from cell extremities, actin patches and cables are reorganized into actin bodies, which are stable actin filament-containing structures. Astonishingly, MTs are also stabilized and rearranged into a novel antiparallel bundle associated with the spindle pole body, named Q-MT bundle. We have identified proteins involved in this process and propose a molecular model for Q-MT bundle formation. Finally and importantly, we reveal that Q-MT bundle elongation is involved in polarity reestablishment upon quiescence exit and thereby the efficient return to the proliferative state. Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.