ArticleProceedings of the National Academy of Sciences of the United States of America2015
Hydrodynamic collective effects of active protein machines in solution and lipid bilayers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions.Nature communications · 2025Article
- Preserving enzyme conformation and catalytic efficiency in crowded and active environments.Nanoscale advances · 2025Article
- Motorless transport of microtubules along tubulin, RanGTP, and salt gradients.Nature communications · 2024Article
- Macromolecular Crowding, Phase Separation, and Homeostasis in the Orchestration of Bacterial Cellular Functions.Chemical reviews · 2024Review
- Early Subcellular Hepatocellular Alterations in Mice Post Hydrodynamic Transfection: An Explorative Study.Cancers · 2023Article
- Perspective: a stirring role for metabolism in cells.Molecular systems biology · 2022Review
- Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices.Micromachines · 2021Review
- Fundamentals and applications of enzyme powered micro/nano-motors.Bioactive materials · 2021Review
- Modelling lipid systems in fluid with Lattice Boltzmann Molecular Dynamics simulations and hydrodynamics.Scientific reports · 2019Article
- Simple mechanics of protein machines.Journal of the Royal Society, Interface · 2019Article
- Intrinsic enzymatic properties modulate the self-propulsion of micromotors.Nature communications · 2019Article
- Enhanced Diffusion of Catalytically Active Enzymes.ACS central science · 2019Review
- A Thermodynamic Limit on the Role of Self-Propulsion in Enhanced Enzyme Diffusion.Biophysical journal · 2019Article
- Fluctuation-induced hydrodynamic coupling in an asymmetric, anisotropic dumbbell.The European physical journal. E, Soft matter · 2019Article
- Catalytic enzymes are active matter.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Impact of hydrodynamic interactions on protein folding rates depends on temperature.Physical review. E · 2018Article
- Enzyme leaps fuel antichemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multiscale simulation of molecular processes in cellular environments.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cytoplasm and biomembranes in biological cells contain large numbers of proteins that cyclically change their shapes. They are molecular machines that can function as molecular motors or carry out various other tasks in the cell. Many enzymes also undergo conformational changes within their turnover cycles. We analyze the advection effects that nonthermal fluctuating hydrodynamic flows induced by active proteins have on other passive molecules in solution or membranes. We show that the diffusion constants of passive particles are enhanced substantially. Furthermore, when gradients of active proteins are present, a chemotaxis-like drift of passive particles takes place. In lipid bilayers, the effects are strongly nonlocal, so that active inclusions in the entire membrane contribute to local diffusion enhancement and the drift. All active proteins in a biological cell or in a membrane contribute to such effects and all passive particles, and the proteins themselves, will be subject to them.
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