ArticleProceedings of the National Academy of Sciences of the United States of America2015
Synchronizing theta oscillations with direct-current stimulation strengthens adaptive control in the human brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07196423 (Glutamate Changes as a New Neurocognitive Marker in Psychosis), which is not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glutamate Changes as a New Neurocognitive Marker in Psychosis
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Transcranial Direct Current Stimulation (tDCS) in the Normalization of Brain Activation in Patients with Neuropsychiatric Disorders: A Systematic Review of Neurophysiological and Neuroimaging Studies.Neural plasticity · 2020Pooled it
- Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study.Neural plasticity · 2019Trial
- Stimulation of Dorsolateral Prefrontal Cortex Enhances Adaptive Cognitive Control: A High-Definition Transcranial Direct Current Stimulation Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- Preliminary investigation of the effects of γ-tACS on working memory in schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2016Trial
- Efficacy and Safety of Transcranial Alternating Current Stimulation Compared to Transcranial Direct Current Stimulation in the Treatment of Psychiatric & Neurological Disorders: A Systematic Review of Head-to-head Trials.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Review
- Trial-By-Trial Changes in Neural Indices of Performance Monitoring Uniquely Correspond to Behavioral Adjustments During a Flanker Task.Human brain mapping · 2026Article
- Neuroscientific therapies for subjective tinnitus.Journal of Zhejiang University. Science. B · 2026Review
- Medial Frontal Theta Reduction Impairs Rule Switching via Prediction Error.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Attention and inhibition deficits in narcolepsy type 1: behavioral and electrophysiological markers.Translational psychiatry · 2025Article
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
- Neuromodulation with transcranial direct current stimulation contributes to motor function recovery via microglia in spinal cord injury.Scientific reports · 2024Article
- Transcranial Direct Current Stimulation Decreases P3 Amplitude and Inherent Delta Activity during a Waiting Impulsivity Paradigm: Crossover Study.Brain sciences · 2024Article
- Effects of continuous versus intermittent theta-burst TMS on fMRI connectivity.Frontiers in human neuroscience · 2024Article
- Towards a mechanistic understanding of the role of error monitoring and memory in social anxiety.bioRxiv : the preprint server for biology · 2023Article
- Neurophysiological Measures of Proactive and Reactive Control in Negative Template Use.Journal of cognitive neuroscience · 2023Article
- Reductions in regional theta power and fronto-parietal theta-gamma phase-amplitude coupling during gaze processing in bipolar disorder.Psychiatry research. Neuroimaging · 2023Article
- Modeling brain dynamics and gaze behavior: Starting point bias and drift rate relate to frontal midline theta oscillations.NeuroImage · 2023Article
- Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder.Journal of psychiatric research · 2023Article
- Estimation of brain tissue response by electrical stimulation in a subject-specific model implemented by conductivity tensor imaging.Frontiers in neuroscience · 2023Article
4 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
Executive control and flexible adjustment of behavior following errors are essential to adaptive functioning. Loss of adaptive control may be a biomarker of a wide range of neuropsychiatric disorders, particularly in the schizophrenia spectrum. Here, we provide support for the view that oscillatory activity in the frontal cortex underlies adaptive adjustments in cognitive processing following errors. Compared with healthy subjects, patients with schizophrenia exhibited low frequency oscillations with abnormal temporal structure and an absence of synchrony over medial-frontal and lateral-prefrontal cortex following errors. To demonstrate that these abnormal oscillations were the origin of the impaired adaptive control in patients with schizophrenia, we applied noninvasive dc electrical stimulation over the medial-frontal cortex. This noninvasive stimulation descrambled the phase of the low-frequency neural oscillations that synchronize activity across cortical regions. Following stimulation, the behavioral index of adaptive control was improved such that patients were indistinguishable from healthy control subjects. These results provide unique causal evidence for theories of executive control and cortical dysconnectivity in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.