ArticleProceedings of the National Academy of Sciences of the United States of America2015
The MYB36 transcription factor orchestrates Casparian strip formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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131 citing papers in PubMed, 311 citations in OpenAlex.
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- Single-nucleus transcriptome profiling unveils cell-type-specific ethylene and TOR signaling in tomato.Horticulture research · 2026Article
- The GAPLESS-OsCASP complex mediates Casparian strip formation for proper localization and abundance of endodermal proteins in rice.Science advances · 2026Article
- Article
- Genome-wide analysis of the R2R3-MYB family reveals potential regulators of lignin and tricin metabolism in the model grass Setaria viridis.Molecular genetics and genomics : MGG · 2026Article
- Root cell wall plasticity in iron homeostasis: an overlooked frontier in plant nutrition.The New phytologist · 2026Review
- Genome Assembly of Three Shrub Mangroves in the Genus Acanthus Reveals Two Polyploidy Events and Expansion of Genes Linked to Root Adaptation in Coastal Habitats.GigaScience · 2026Article
- Regulatory Roles of MYB Transcription Factors in Root Barrier Under Abiotic Stress.Plants (Basel, Switzerland) · 2026Review
- The lignin deposition responses of different poplar root systems to salt stress.Frontiers in plant science · 2026Article
- Clathrin-mediated endocytosis regulates root endodermal suberization via ROS.The New phytologist · 2025Article
- Dual roles of suberin deposition at the endodermal Casparian strip in manganese uptake of rice.Journal of experimental botany · 2025Article
- Coordination of cortex modifications in time, space, and under stress.The New phytologist · 2025Review
- Integrated single-cell transcriptomics and spatial metabolomics unveil cellular differentiation and ginsenosides biosynthesis inHorticulture research · 2025Article
- Exogenous gamma amino butyric acid (GABA) enhanced salinity tolerance in wheat by modulating morphological and anatomical traits.Scientific reports · 2025Article
- Transcriptional regulation of thorn tip sclerification in plants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- ONAC005 enhances salt stress tolerance by promoting suberin deposition in root endodermis.The Plant journal : for cell and molecular biology · 2025Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
The endodermis in roots acts as a selectivity filter for nutrient and water transport essential for growth and development. This selectivity is enabled by the formation of lignin-based Casparian strips. Casparian strip formation is initiated by the localization of the Casparian strip domain proteins (CASPs) in the plasma membrane, at the site where the Casparian strip will form. Localized CASPs recruit Peroxidase 64 (PER64), a Respiratory Burst Oxidase Homolog F, and Enhanced Suberin 1 (ESB1), a dirigent-like protein, to assemble the lignin polymerization machinery. However, the factors that control both expression of the genes encoding this biosynthetic machinery and its localization to the Casparian strip formation site remain unknown. Here, we identify the transcription factor, MYB36, essential for Casparian strip formation. MYB36 directly and positively regulates the expression of the Casparian strip genes CASP1, PER64, and ESB1. Casparian strips are absent in plants lacking a functional MYB36 and are replaced by ectopic lignin-like material in the corners of endodermal cells. The barrier function of Casparian strips in these plants is also disrupted. Significantly, ectopic expression of MYB36 in the cortex is sufficient to reprogram these cells to start expressing CASP1-GFP, correctly localize the CASP1-GFP protein to form a Casparian strip domain, and deposit a Casparian strip-like structure in the cell wall at this location. These results demonstrate that MYB36 is controlling expression of the machinery required to locally polymerize lignin in a fine band in the cell wall for the formation of the Casparian strip.
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