ArticleScientific reports2015
High performance wash-free magnetic bioassays through microfluidically enhanced particle specificity.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Microfluidic Integration of Magnetically Functionalized Microwires for Flow Cytometry Protein Quantification.Materials (Basel, Switzerland) · 2025Article
- Magnetic Particle Spectroscopy for Point-of-Care: A Review on Recent Advances.Sensors (Basel, Switzerland) · 2023Review
- Giant Magnetoresistance Biosensors for Food Safety Applications.Sensors (Basel, Switzerland) · 2022Review
- Magnetic supercluster particles for highly sensitive magnetic biosensing of proteins.Mikrochimica acta · 2022Article
- Giant Magnetoresistance Biosensors in Biomedical Applications.ACS applied materials & interfaces · 2022Review
- Microfluidic communicating vessel chip for expedited and automated immunomagnetic assays.Lab on a chip · 2018Article
- Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors.Theranostics · 2018Article
- Longitudinal Monitoring of Antibody Responses against Tumor Cells Using Magneto-nanosensors with a Nanoliter of Blood.Nano letters · 2017Article
- Giant Magnetoresistive Biosensors for Time-Domain Magnetorelaxometry: A Theoretical Investigation and Progress Toward an Immunoassay.Scientific reports · 2017Article
- Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes.Nature biomedical engineering · 2017Article
- Magnetic fingerprints of rolling cells for quantitative flow cytometry in whole blood.Scientific reports · 2016Article
- Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus.Scientific reports · 2016Article
- Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Magnetic biosensors have emerged as a sensitive and versatile platform for high performance medical diagnostics. These magnetic biosensors require well-tailored magnetic particles as detection probes, which need to give rise to a large and specific biological signal while showing very low nonspecific binding. This is especially important in wash-free bioassay protocols, which do not require removal of particles before measurement, often a necessity in point of care diagnostics. Here we show that magnetic interactions between magnetic particles and magnetized sensors dramatically impact particle transport and magnetic adhesion to the sensor surfaces. We investigate the dynamics of magnetic particles' biomolecular binding and magnetic adhesion to the sensor surface using microfluidic experiments. We elucidate how flow forces can inhibit magnetic adhesion, greatly diminishing or even eliminating nonspecific signals in wash-free magnetic bioassays, and enhancing signal to noise ratios by several orders of magnitude. Our method is useful for selecting and optimizing magnetic particles for a wide range of magnetic sensor platforms.
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Registered trials
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