ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Impact of occult renal dysfunction on postoperative acute kidney injury and late prognosis in elderly patients undergoing coronary artery bypass.BMC nephrology · 2026Observational
- Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction.Journal of cardiovascular translational research · 2024Article
- Causal relationship from heart failure to kidney function and CKD: A bidirectional two-sample mendelian randomization study.PloS one · 2023Article
- Systemic mapping of organ plasma extravasation at multiple stages of chronic heart failure.Frontiers in physiology · 2023Article
- Modifiable Individual Risks of Perioperative Blood Transfusions and Acute Postoperative Complications in Total Hip and Knee Arthroplasty.Journal of personalized medicine · 2021Article
- Altered Hemodynamics and End-Organ Damage in Heart Failure: Impact on the Lung and Kidney.Circulation · 2020Review
- Cardiac and renal function interactions in heart failure with reduced ejection fraction: A mathematical modeling analysis.PLoS computational biology · 2020Article
- Invasive hemodynamics and cardiac biomarkers to predict outcomes after percutaneous edge-to-edge mitral valve repair in patients with severe heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Association between central venous pressure as assessed by echocardiography, left ventricular function and acute cardio-renal syndrome in patients with ST segment elevation myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Observational
- Combined use of lung ultrasound, B-type natriuretic peptide, and echocardiography for outcome prediction in patients with acute HFrEF and HFpEF.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Renal function monitoring in heart failure - what is the optimal frequency? A narrative review.British journal of clinical pharmacology · 2018Review
- Clinical characteristics and treatment of renal artery fibromuscular dysplasia with percutaneous transluminal angioplasty: a long-term follow-up study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Prognostic role of N-terminal pro-brain natriuretic peptide in asymptomatic hypertensive and diabetic patients in primary care: impact of age and gender : Results from the PROBE-HF study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study.Diabetes & vascular disease researchObservational
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLittle is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF). METHODS AND
resultsWe prospectively studied effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in 73 HFREF patients with (125)I-iothalamate/(131)I-hippuran clearances with a mean follow-up of 34.6 ± 4.4 months. Fifteen percent were female, with age 58 ± 12 years and left ventricular ejection fraction (LVEF) 29 ± 10%. Baseline GFR was 81 ± 23 mL/min/1.73 m(2) and declined 0.6 ± 4.7 mL/min/1.73 m(2) per year. Baseline ERPF was 292 ± 83 mL/min/1.73 m(2) and declined 4.3 ± 19 mL/min/1.73 m(2) per year. Of the baseline variables, older age and high urinary kidney injury molecule-1 were the only variables associated with GFR decline (p < 0.05). Following stepwise backward analysis, only age (p < 0.001) remained significant. In addition, we found an association between change in GFR and changes in ERPF, N-terminal pro-brain natriuretic peptide and renovascular resistance. In the multivariable analysis, only the change in ERPF remained significantly associated with a change in GFR (p < 0.001).
conclusionIn this cohort of stable chronic HFREF patients, the average decline in GFR over time was small. The decline of GFR was associated with a higher age and a lower baseline GFR, and was strongly related to changes in renal perfusion.
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