ArticleScientific reports2015
Superdiffusion dominates intracellular particle motion in the supercrowded cytoplasm of pathogenic Acanthamoeba castellanii.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 218 citations in OpenAlex.
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- Subdiffusion from competition between multi-exponential friction memory and energy barriers.The European physical journal. E, Soft matter · 2025Article
- Time-Lapse Tracking of Acanthamoeba castellanii Trophozoite Activity During Exposure to Contact Lens Disinfectants.Investigative ophthalmology & visual science · 2025Article
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- Quasi-Diffusion Imaging: Application to Ultra-High b-Value and Time-Dependent Diffusion Images of Brain Tissue.NMR in biomedicine · 2025Article
- Heterogeneous model for superdiffusive movement of dense core vesicles in C. elegans.Scientific reports · 2025Article
- Speckle fluctuations reveal dynamics of microparticles in fibrin scaffolds in a model of bacterial infection.npj biological physics and mechanics · 2025Article
- Deciphering the intracellular forces shaping mitochondrial motion.Scientific reports · 2024Article
- Anomalous dynamics of a passive droplet in active turbulence.Nature communications · 2024Article
- Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma.Journal of bacteriology · 2024Review
- Record ages of non-Markovian scale-invariant random walks.Nature communications · 2023Article
- Target search by an imported conjugative DNA element for a unique integration site along a bacterial chromosome during horizontal gene transfer.Nucleic acids research · 2023Article
- Topological bio-scaling analysis as a universal measure of protein folding.Royal Society open science · 2022Article
- Impact of neurite alignment on organelle motion.Journal of the Royal Society, Interface · 2022Article
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- Lévy Walk Dynamics in an External Constant Force Field in Non-Static Media.Journal of statistical physics · 2022Article
- An update on passive transport in and out of plant cells.Plant physiology · 2021Review
- Transcription-dependent confined diffusion of enzymes within subcellular spaces of the bacterial cytoplasm.BMC biology · 2021Article
- Continuous Real-Time Motility Analysis ofPathogens (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acanthamoebae are free-living protists and human pathogens, whose cellular functions and pathogenicity strongly depend on the transport of intracellular vesicles and granules through the cytosol. Using high-speed live cell imaging in combination with single-particle tracking analysis, we show here that the motion of endogenous intracellular particles in the size range from a few hundred nanometers to several micrometers in Acanthamoeba castellanii is strongly superdiffusive and influenced by cell locomotion, cytoskeletal elements, and myosin II. We demonstrate that cell locomotion significantly contributes to intracellular particle motion, but is clearly not the only origin of superdiffusivity. By analyzing the contribution of microtubules, actin, and myosin II motors we show that myosin II is a major driving force of intracellular motion in A. castellanii. The cytoplasm of A. castellanii is supercrowded with intracellular vesicles and granules, such that significant intracellular motion can only be achieved by actively driven motion, while purely thermally driven diffusion is negligible.
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