ArticleSurgery today2016
Correlation between histological invasiveness and the computed tomography value in pure ground-glass nodules.
Article in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 68 citations in OpenAlex.
- The effect of radio-frequency ablation in treating pulmonary ground glass nodule patients and its influence on pulmonary function.African health sciences · 2024Trial
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- Qualitative and quantitative CT analyses of the solid component in lung adenocarcinoma for predicting invasiveness.Japanese journal of radiology · 2025Article
- Low-dose ultrahigh-resolution PCCT enhances subsolid nodule characterization.La Radiologia medica · 2025Article
- Exploration of CT-based discrimination and diagnosis of various pathological types of ground glass nodules in the lungs.BMC medical imaging · 2025Article
- Radiomics integration based on intratumoral and peritumoral computed tomography improves the diagnostic efficiency of invasiveness in patients with pure ground-glass nodules: a machine learning, cross-sectional, bicentric study.Journal of cardiothoracic surgery · 2025Article
- Differentiation of Minute Pulmonary Meningothelial-Like Nodules and Adenocarcinoma In situ with CT RadiomicsCurrent medical imaging · 2025Article
- CT-based nomogram for predicting EGFR mutation status in ground-glass nodules of lung adenocarcinoma.Frontiers in immunology · 2025Article
- The value of interlobar fissure semilunar sign based on multifactor joint analysis in predicting the invasiveness of ground glass nodules with interlobar fissure attachment in the lungs.BMC pulmonary medicine · 2024Article
- The value of non-enhanced CT 3D visualization in differentiating stage Ⅰ invasive lung adenocarcinoma between LPA and non-LPA.European journal of radiology open · 2024Article
- Discrimination of invasive lung adenocarcinoma from Lung-RADS category 2 nonsolid nodules through visual assessment: a retrospective study.European radiology · 2024Article
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- Histopathologic fate of resected pulmonary pure ground glass nodule: a systematic review and meta-analysis.Journal of thoracic disease · 2024Article
- The value of CT shape quantification in predicting pathological classification of lung adenocarcinoma.BMC cancer · 2024Article
- A nomogram for predicting invasiveness of lung adenocarcinoma manifesting as pure ground-glass nodules: incorporating subjective CT signs and histogram parameters based on artificial intelligence.Journal of cancer research and clinical oncology · 2023Article
- Growth assessment of pure ground-glass nodules on CT: comparison of density and size measurement methods.Journal of cancer research and clinical oncology · 2023Article
- Radiomics-based analysis of CT imaging for the preoperative prediction of invasiveness in pure ground-glass nodule lung adenocarcinomas.Insights into imaging · 2023Article
- Establishment and validation a prediction model for discrimination of invasive adenocarcinomas for patients with peripheral pulmonary subsolid nodules.Annals of translational medicine · 2022Article
- A CT-based nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodule according to the 2021 WHO classification.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the correlation between histological invasiveness and the computed tomography (CT) value and size in pure ground-glass nodules (GGNs) to determine optimal "follow-up or resection" strategies.
methodsBetween 2001 and 2014, 78 resected, pure GGNs were retrospectively evaluated. The maximum diameter and CT value of pure GGNs were measured using a computer graphics support system.
resultsAll GGNs with a maximum diameter ≤10 mm and CT value ≤-600 Hounsfield units (HU) were considered to be noninvasive lesions, while 21 of 26 (81 %) with a maximum diameter >10 mm and CT value >-600 HU were considered to be invasive lesions. With respect to the correlation between each histological type and pure GGN with a maximum diameter ≤10 mm and CT value ≤-600 HU, the specificity was 90 % and the sensitivity and negative predictive value were both 100 % in atypical adenomatous hyperplasia (AAH), while the specificity was 58 % and the sensitivity and positive predictive value were 0 % in minimally invasive and invasive adenocarcinoma.
conclusionPure GGNs with a maximum diameter of ≤10 mm and CT value of ≤-600 HU are nearly always pre-invasive lesions; therefore, surgery should be carefully selected in such patients.
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