ArticleNature communications2015
Supramolecular amplification of amyloid self-assembly by iodination.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Palladium-triggered bioorthogonal phenylalanine decaging.Nature chemistry · 2026Article
- Matere bond identification in non-crystalline materials by using X-ray photoelectron spectroscopy.Chemical science · 2025Article
- Taxonomy of Chemical Bondings: Opportunities and Challenges.Angewandte Chemie (International ed. in English) · 2025Article
- Computation meets experiment: identification of highly efficient fibrillating peptides.CrystEngComm · 2023Article
- Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments.Protein science : a publication of the Protein Society · 2023Article
- Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4.Drug design, development and therapy · 2023Article
- Salt-Inducible Kinase 2-Triggered Release of Its Inhibitor from Hydrogel to Suppress Ovarian Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Synthesis, Self-Assembly, and Cell Responses of Aromatic IKVAV Peptide Amphiphiles.Molecules (Basel, Switzerland) · 2022Article
- Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Fibril Structure Demonstrates the Role of Iodine Labelling on a Pentapeptide Self-Assembly.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences.ACS biomaterials science & engineering · 2022Article
- Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- Applications of Photoinduced Phenomena in Supramolecularly Arranged Phthalocyanine Derivatives: A Perspective.Molecules (Basel, Switzerland) · 2020Review
- Halogenation of theChemistryOpen · 2020Article
- A Short Peptide Hydrogel with High Stiffness Induced by 3Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Molecular dynamics investigation of halogenated amyloidogenic peptides.Journal of molecular modeling · 2019Article
- Iodination of terminal alkynes using KI/CuSOTetrahedron letters · 2019Article
- In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination.ACS nano · 2019Article
- Analysis of iodinated quorum sensing peptides by LC-UV/ESI ion trap mass spectrometry.Journal of pharmaceutical analysis · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable processes. Noncovalent interactions are key to forming and holding the amyloid structure together. On the other hand, the halogen bond has never been used purposefully to achieve control over amyloid self-assembly. Here we show that single atom replacement of hydrogen with iodine, a halogen-bond donor, in the human calcitonin-derived amyloidogenic fragment DFNKF results in a super-gelator peptide, which forms a strong and shape-persistent hydrogel at 30-fold lower concentration than the wild-type pentapeptide. This is remarkable for such a modest perturbation in structure. Iodination of aromatic amino acids may thus develop as a general strategy for the design of new hydrogels from unprotected peptides and without using organic solvents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.