Trial reportHypertension (Dallas, Tex. : 1979)2015
Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures.
Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01864824 (Air Pollution, Epigenetics and Cardiovascular Health), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta-analyses.Journal of internal medicine · 2022Pooled it
- Inhaled endotoxin induces a systemic neutrophil response without affecting cardiovascular measures in a randomized cross-over exposure study.Inhalation toxicology · 2024Trial
- Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study.Environment international · 2017Trial
- Inflammatory effects of particulate matter air pollution.Environmental science and pollution research international · 2020Review
- Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice.Mycobiology · 2020Article
- Potential gains in life expectancy by attaining daily ambient fine particulate matter pollution standards in mainland China: A modeling study based on nationwide data.PLoS medicine · 2020Article
- Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study.Environment international · 2018Article
- Wildland fire smoke and human health.The Science of the total environment · 2018Review
- B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation: A Pilot Human Intervention Trial.Scientific reports · 2017Article
- Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study.Environmental science. Processes & impacts · 2016Article
Corrections and comments
- Commented on by
Authors and funding
15 authors at 6 institutions in 2 countries.
Jia ZhongFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.). jiazhong@mail.harvard.edu.
Bruce UrchFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Mary SpeckFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Brent A CoullFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Petros KoutrakisFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Peter S ThorneFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
James ScottFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Ling LiuFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Robert D BrookFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Behrooz BehbodFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Heike GibsonFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Frances SilvermanFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Murray A MittlemanFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Andrea A BaccarelliFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
Diane R GoldFrom the Department of Environmental Health (J.Z., P.K., B.B., H.G., A.A.B., D.R.G.), Department of Biostatistics (B.A.C.), and Department of Epidemiology (M.A.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Division of Occupational & Environmental Health, Dalla Lana School of Public Health (J.S., F.S.), Department of Medicine (B.U., J.S., F.S.), and Divisions of Occupational and Respiratory Medicine, Department of Medicine (F.S.), University of Toronto, Toronto, Ontario, Canada; Department of Occupational and Environmental Health, University of Iowa (P.S.T.); Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada (L.L.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (R.D.B.); Li Ka Shing Knowledge Institute (F.S.), St Michael's Hospital (M.S., J.S., F.S.), Toronto, Ontario, Canada; Southern Ontario Center for Atmospheric Aerosol Research, Toronto, Ontario, Canada (F.S.); and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.R.G.).
St. Michael's Hospital · CAHealth Canada · CAPublic Health Ontario · CAUniversity of Iowa · USUniversity of Michigan–Ann Arbor · USUniversity of Toronto · CA
Funding
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MEffect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI MITTLEMAN, MURRAY A · 1999 to 2009
$17.4MNIEHS NIH HHS ES000002NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30ES005605ORD VA RD-83241601ORD VA RD-83479801
Abstract
Short-term exposure to particulate matter (PM) is associated with increased blood pressure (BP) in epidemiological studies. Understanding the impact of specific PM components on BP is essential in developing effective risk-reduction strategies. We investigated the association between endotoxin and β-1,3-d-Glucan-two major biological PM components-and BP. We also examined whether vascular endothelial growth factor, a vasodilatory inflammatory marker, modified these associations. We conducted a single-blind, randomized, crossover trial of controlled human exposure to concentrated ambient particles with 50 healthy adults. Particle-associated-endotoxin and β-1,3-d-Glucan were sampled using polycarbonate-membrane-filters. Supine resting systolic BP and diastolic BP were measured pre-, 0.5-hour post-, and 20-hour postexposure. Urine vascular endothelial growth factor concentration was determined using enzyme-linked immunosorbant assay and creatinine-corrected. Exposures to endotoxin and β-1,3-d-Glucan for 130 minutes were associated with increases in BPs: at 0.5-hour postexposure, every doubling in endotoxin concentration was associated with 1.73 mm Hg higher systolic BP (95% confidence interval, 0.28, 3.18; P=0.02) and 2.07 mm Hg higher diastolic BP (95% confidence interval, 0.74, 3.39; P=0.003); every doubling in β-1,3-d-Glucan concentration was associated with 0.80 mm Hg higher systolic BP (95% confidence interval, -0.07, 1.67; P=0.07) and 0.88 mm Hg higher diastolic BP (95% confidence interval, 0.09, 1.66; P=0.03). Vascular endothelial growth factor rose after concentrated ambient particle endotoxin exposure and attenuated the association between endotoxin and 0.5-hour postexposure diastolic BP (Pinteraction=0.02). In healthy adults, short-term endotoxin and β-1,3-d-Glucan exposures were associated with increased BP. Our findings suggest that the biological PM components contribute to PM-related cardiovascular outcomes, and postexposure vascular endothelial growth factor elevation might be an adaptive response that attenuates these effects.
Indexed as
Air PollutantsAdolescentAdultbeta-GlucansBlood PressureBlood Pressure DeterminationCross-Over StudiesEndotoxinsFemaleHumansInhalation ExposureMaleMiddle AgedParticulate MatterProteoglycansSingle-Blind MethodAir Pollutantsbeta-GlucansEndotoxinsParticulate Matterpolysaccharide-KProteoglycansair pollutionblood pressureendotoxinvascular endothelial growth factorβ-1,3-d-Glucan
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT01864824ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.