Evidence map›Paper›PMID 26123602›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Quality of life across chemotherapy lines in patients with advanced colorectal cancer: a prospective single-center observational study.

Beate Mayrbäurl, Johannes M Giesinger, Sonja Burgstaller, Gudrun Piringer, Bernhard Holzner, Josef Thaler

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 8 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 8 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  9. Observational
  10. Review
  11. Article
  12. Article
  13. Quality of life in Tunisian colorectal cancer patients: a cross-sectional study.Journal of cancer research and clinical oncology · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Primary and metastatic peritoneal surface malignancies.Nature reviews. Disease primers · 2021
    Review
  18. Article
  19. Article
  20. Quality of life of patients with gastrointestinal cancers undergoing chemotherapy.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Beate MayrbäurlDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, 4600, Wels, Austria. beate.mayrbaeurl@kabelkom.at.
Johannes M GiesingerDepartment of Psychiatry and Psychotherapy, Innsbruck Medical University, Anichstrasse 35, A-6020, Innsbruck, Austria.
Sonja BurgstallerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, 4600, Wels, Austria.
Gudrun PiringerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, 4600, Wels, Austria.
Bernhard HolznerDepartment of Psychiatry and Psychotherapy, Innsbruck Medical University, Anichstrasse 35, A-6020, Innsbruck, Austria.
Josef ThalerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, 4600, Wels, Austria.
Klinikum Wels-Grieskirchen · ATInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPalliative chemotherapy in patients with nonresectable advanced colorectal carcinoma is performed to prolong survival, alleviate tumor-associated symptoms, and maintain or improve health-related quality of life (HRQOL). In this prospective single-center observational study, we assessed HRQOL across the various lines of palliative chemotherapy.

methodsHRQOL data were acquired using the EORTC Quality of Life Questionnaire-C30 (QLQ-C30) questionnaire. The first assessment was performed at the beginning of each chemotherapy line, the second after three cycles, and the third at the end of chemotherapy. Further assessments were conducted during checkups every 3 months in our outpatient unit.

resultsIn total, 100 consecutive patients with colorectal carcinoma (mean age 66.4 years; 60 % men) treated with palliative chemotherapy were recruited. Generally, QOL deteriorated constantly across time. Physical functioning, fatigue, pain, dyspnea, and appetite worsened steadily from first-line chemotherapy to the later treatment phase. Global QOL, emotional functioning, and role functioning improved slightly after the end of first-line chemotherapy, deteriorated during second-line chemotherapy to the level of first-line chemotherapy, and further deteriorated in the later treatment phases. In additional analyses, we found the largest differences between patients with and without a treatment response for pain (19.0 vs. 37.2 points) and appetite loss (17.4 vs. 32.7 points).

conclusionThe individual QOL domains deteriorated constantly across time. Our data indicate that patients undergoing first- and second-line palliative chemotherapy experience stabilization of global QOL and psychosocial symptoms. We also found that unselected patients who achieved a treatment response had a lower symptom burden and better QOL than did patients with progressive disease.

Indexed as

AdultAgedAged, 80 and overColorectal NeoplasmsFemaleHumansMaleMiddle AgedPalliative CareProspective StudiesQuality of LifeSurveys and QuestionnairesAdvanced colorectal cancerElectronic patient-reported outcome monitoringPalliative chemotherapyQuality of life

Identifiers

PMID26123602
OpenAlexW789887766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.