ArticleScientific reports2015
Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Cell-particles interaction - selective uptake and transport of microdiamonds.Communications biology · 2024Article
- Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications.Pharmaceutics · 2024Review
- Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability.Frontiers in bioengineering and biotechnology · 2024Article
- Simultaneous Nanorheometry and Nanothermometry Using Intracellular Diamond Quantum Sensors.ACS nano · 2023Article
- Engineering poly- and micelleplexes for nucleic acid delivery - A reflection on their endosomal escape.Journal of controlled release : official journal of the Controlled Release Society · 2023Review
- Nanoparticles-mediated CRISPR-Cas9 gene therapy in inherited retinal diseases: applications, challenges, and emerging opportunities.Journal of nanobiotechnology · 2022Review
- Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Intracellular Quantum Sensing of Free-Radical Generation Induced by Acetaminophen (APAP) in the Cytosol, in Mitochondria and the Nucleus of Macrophages.ACS sensors · 2022Article
- Intracellular Relaxometry, Challenges, and Future Directions.ACS central science · 2022Review
- Emerging Diamond Quantum Sensing in Bio-Membranes.Membranes · 2022Review
- Functionalized Fluorescent Nanodiamonds for Simultaneous Drug Delivery and Quantum Sensing in HeLa Cells.ACS applied materials & interfaces · 2022Article
- Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles.Pharmaceutical research · 2022Review
- Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures.International journal of molecular sciences · 2021Review
- Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation.Open biology · 2021Review
- From Nanoparticles to Cancer Nanomedicine: Old Problems with New Solutions.Nanomaterials (Basel, Switzerland) · 2021Review
- Quantum monitoring of cellular metabolic activities in single mitochondria.Science advances · 2021Article
- Article
- Nanoscopy for endosomal escape quantification.Nanoscale advances · 2021Review
- Targeting Nanodiamonds to the Nucleus in Yeast Cells.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prickly nanodiamonds easily entered cells via endocytosis followed by unique intracellular translocation characteristics—quick endosomal escape followed by stable residence in cytoplasm. Endosomal membrane rupturing is identified as the major route of nanodiamonds' escaping the vesicle confinement and to the cytoplasm. Little cytotoxicity is observed to associate with the nanodiamonds' cytosolic release. Such features enable its application for gene delivery, which requires both effective cellular uptake and cytosolic release of the gene. Taking green fluorescent protein gene as an example, we demonstrate the successful cytosolic delivery and expression of such a gene using the prickly nanodiamonds as carrier.
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Registered trials
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