Evidence map›Paper›PMID 26123524›Full record

ArticleNature communications2015

PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine.

Shu-Yun Kuo, Chia-Lin Wu, Min-Yen Hsieh, Chen-Ta Lin, Rong-Kun Wen, Lien-Cheng Chen, Yu-Hui Chen, Yhu-Wei Yu, Horng-Dar Wang, Yi-Ju Su and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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  8. Journal of developmental biology · 2021
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  14. Characterization of the Sexually DimorphicFrontiers in physiology · 2018
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Shu-Yun KuoDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Chia-Lin Wu1] Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 33302 Taoyuan, Taiwan [2] Department of Medical Research, Chang Gung Memorial Hospital, 33305 Taoyuan, Taiwan.
Min-Yen HsiehDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Chen-Ta LinDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Rong-Kun WenDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Lien-Cheng ChenDepartment of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, 70703 Tainan, Taiwan.
Yu-Hui ChenDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Yhu-Wei YuDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Horng-Dar WangInstitute of Biotechnology, Institute of Systems Neuroscience, and Department of Life Science, National Tsing Hua University, 30013 Hsinchu, Taiwan.ORCID 0000000195703611
Yi-Ju SuDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Chun-Ju LinDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Cian-Yi YangDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Hsien-Yu GuanDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
Pei-Yu WangGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, 10051 Taipei, Taiwan.
Tsuo-Hung Lan1] Department of Psychiatry, School of Medicine, National Yang Ming University, 11221 Taipei, Taiwan [2] Department of Psychiatry, Taichung Veterans General Hospital, 40705 Taichung, Taiwan.
Tsai-Feng FuDepartment of Applied Chemistry, National Chi Nan University, 54561 Nantou, Taiwan.
National Chi Nan University · TWChang Gung University · TWChung Hwa University of Medical Technology · TWNational Taiwan University · TWNational Tsing Hua University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlling male sexual desire. A number of studies across species suggest that dopamine (DA) affects sexual desire. Here we use genetic tools and behavioural assays to identify a novel subset of DA neurons that regulate age-associated male courtship activity in Drosophila. We find that increasing DA levels in a subset of cells in the PPL2ab neuronal cluster is necessary and sufficient for increased sustained courtship in both young and aged male flies. Our results indicate that preventing the age-related decline in DA levels in PPL2ab neurons alleviates diminished courtship behaviours in male Drosophila. These results may provide the foundation for deciphering the circuitry involved in sexual motivation in the male Drosophila brain.

Indexed as

AgingAnimalsDopamineDopaminergic NeuronsDrosophilaMaleSexual Behavior, AnimalDopamine

Identifiers

PMID26123524
PMCPMC4491191
OpenAlexW2268895644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.