ArticlePsychiatry research2015
Alterations in hippocampal connectivity across the psychosis dimension.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 90 citations in OpenAlex.
- Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis.Psychological medicine · 2025Trial
- Unsupervised Clustering of ACC and Hippocampal Metabolites Identifies Subgroups in Antipsychotic-Naïve First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- Altered functional connectivity of the hippocampus in cortico-subcortical networks in early-stage and emerging psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks.Diagnostics (Basel, Switzerland) · 2025Article
- Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets.Science advances · 2025Article
- Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.Nature. Mental health · 2025Article
- Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review.Translational psychiatry · 2025Review
- Functional ultrasound imaging and prewhitening analysis reveal MK-801-induced disruption of brain network connectivity.Frontiers in pharmacology · 2025Article
- Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.Biological psychiatry global open science · 2023Article
- Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study.Psychiatry research · 2023Article
- Aberrant intra- and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia.CNS neuroscience & therapeutics · 2023Article
- Hippocampal Hyperconnectivity to the Visual Cortex Predicts Treatment Response.Schizophrenia bulletin · 2023Article
- Hippocampal circuit dysfunction in psychosis.Translational psychiatry · 2022Review
- Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Comparative analysis of default mode networks in major psychiatric disorders using resting-state EEG.Scientific reports · 2021Article
- Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory.NPJ schizophrenia · 2021Article
- Modular, Circuit-Based Interventions Rescue Hippocampal-Dependent Social and Spatial Memory in a 22q11.2 Deletion Syndrome Mouse Model.Biological psychiatry · 2020Article
- Disordered directional brain network interactions during learning dynamics in schizophrenia revealed by multivariate autoregressive models.Human brain mapping · 2020Article
- Timing of menarche and abnormal hippocampal connectivity in youth at clinical-high risk for psychosis.Psychoneuroendocrinology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Recent evidence demonstrates that hippocampal hyperactivity helps mediate psychosis. Using resting state functional magnetic resonance imaging (rsfMRI), we examined hippocampal connectivity alterations in individuals with psychosis (PS) versus healthy controls (HC). Because of its putative greater involvement in psychiatric disorders, we hypothesized that the anterior hippocampus network would show greater dysconnectivity in psychosis. We tested rsfMRI connectivity in 88 PS (including 21 with schizophrenia; 40 with schizoaffective disorder; 27 with psychotic bipolar I disorder) and 65 HC. Seed-based voxel-wise connectivity analyses were carried out using whole, anterior, and posterior hippocampal seeds. No significant differences in functional hippocampal connectivity were found across the three conventional diagnoses. PS were then contrasted with HC, showing strong reductions in anterior hippocampal connectivity to anterior neocortical regions, including medial frontal and anterior cingulate cortices, as well as superior temporal gyrus, precuneus, thalamus and cerebellum. Posterior hippocampal seeds also demonstrated decreased connectivity in PS, with fewer dysconnected regions and a posterior/cerebellar distribution. Whole hippocampal outcomes were consistent with anterior/posterior hippocampal connectivity changes. Connectivity alterations did not correlate with cognition, clinical symptoms, or medication effect variables. Our results suggest a psychosis network of decreased hippocampal connectivity with limbic and frontal contributions, independent of diagnostic categories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.