ArticleEuropean radiology2016
Correlation of force control with regional spinal DTI in patients with cervical spondylosis without signs of spinal cord injury on conventional MRI.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01243684 (Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Upper Limb Outcome Measures Used in Stroke Rehabilitation Studies: A Systematic Literature Review.PloS one · 2016Pooled it
- Efficacy of interactive manual dexterity training after stroke: a pilot single-blinded randomized controlled trial.Journal of neuroengineering and rehabilitation · 2023Trial
- Intramedullary Strain During Neck Extension is Associated with Microstructural Spinal Cord Injury in Degenerative Cervical Myelopathy.Annals of biomedical engineering · 2026Article
- Assessment of acute traumatic cervical spinal cord injury using conventional magnetic resonance imaging in combination with diffusion tensor imaging-tractography: a retrospective comparative study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Changes and clinical correlation of diffusion tensor imaging parameters of compressed spinal cord and nerve root in patients with cervical spondylosis.BMC medical imaging · 2022Article
- Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review.Journal of clinical medicine · 2022Review
- A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time.Global spine journal · 2022Article
- Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression.European journal of neurology · 2021Article
- Predictive value of flexion and extension diffusion tensor imaging in the early stage of cervical myelopathy.Neuroradiology · 2018Article
- A preliminary study of 3.0-T magnetic resonance diffusion tensor imaging in cervical spondylotic myelopathy.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
- Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury.Neural regeneration research · 2018Article
- Observational
- Application of diffusion tensor imaging in quantitatively monitoring chronic constriction injury of rabbit sciatic nerves: correlation with histological and functional changes.The British journal of radiology · 2018Article
- The functional relevance of diffusion tensor imaging in comparison to conventional MRI in patients with cervical compressive myelopathy.Skeletal radiology · 2017Article
- Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries.Quantitative imaging in medicine and surgery · 2017Review
- Kinetic DTI of the cervical spine: diffusivity changes in healthy subjects.Neuroradiology · 2016Article
- Recent Developments in Diffusion Tensor Imaging of Brain.Radiology - open journalArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to investigate spinal cord structure in patients with cervical spondylosis where conventional MRI fails to reveal spinal cord damage.
methodsWe performed a cross-sectional study of patients with cervical spondylosis without conventional MRI findings of spinal cord damage and healthy controls. Subjects were studied using spinal diffusion tensor imaging (DTI), precision grip and foot force-tracking tasks, and a clinical examination including assessment of neurological signs. A regional analysis of lateral and medial spinal white matter across multiple cervical levels (C1-C5) was performed.
resultsDTI revealed reduced fractional anisotropy (FA) and increased radial diffusivity (RD) in the lateral spinal cord at the level of greatest compression (lowest Pavlov ratio) in patients (p < 0.05). Patients with spondylosis had greater error and longer release duration in both grip and foot force-tracking. Similar spinal cord deficits were present in patients without neurological signs. Increased error in grip and foot tracking (low accuracy) correlated with increased RD in the lateral spinal cord at the level of greatest compression (p ≤ 0.01).
conclusionsSpinal DTI can detect subtle spinal cord damage of functional relevance in cervical spondylosis, even in patients without signs on conventional T2-imaging and without neurological signs. KEY POINTS: DTI reveals spinal cord changes in cervical spondylosis with few symptoms. DTI changes were present despite normal spinal cord on conventional MRI. DTI parameters correlated with force control accuracy in hand and foot. Spinal DTI is a promising technique for patients with cervical spondylosis.
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