ArticleNature communications2015
Early emergence of Yersinia pestis as a severe respiratory pathogen.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 95 citations in OpenAlex.
- Article
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- Unveiling the dance of evolution: Pla-mediated cleavage of Ymt modulates the virulence dynamics ofmBio · 2024Article
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- The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights.Microorganisms · 2024Review
- AncientProceedings. Biological sciences · 2023Article
- A frameshift ineLife · 2023Article
- Lung microbiome and origins of the respiratory diseases.Current research in immunology · 2023Review
- Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution.Nature communications · 2022Article
- The Evolution of a Specialized, Highly Virulent Fish Pathogen through Gene Loss and Acquisition of Host-Specific Survival Mechanisms.Applied and environmental microbiology · 2022Article
- Contributions of Yersinia pestis outer membrane protein Ail to plague pathogenesis.Current opinion in infectious diseases · 2022Review
- Emergence and spread of ancestralProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Stone AgeProceedings of the National Academy of Sciences of the United States of America · 2022Article
- PgtE Enzyme ofFrontiers in immunology · 2022Article
- Antibiotic Therapy of Plague: A Review.Biomolecules · 2021Review
- The Diverse Roles of the Global Transcriptional Regulator PhoP in the Lifecycle ofPathogens (Basel, Switzerland) · 2020Review
- Review
- Yersinia pestis strains from Latvia show depletion of the pla virulence gene at the end of the second plague pandemic.Scientific reports · 2020Article
- Identification and characterization of OmpT-like proteases in uropathogenic Escherichia coli clinical isolates.MicrobiologyOpen · 2019Article
- Modeling Pneumonic Plague in Human Precision-Cut Lung Slices Highlights a Role for the Plasminogen Activator Protease in Facilitating Type 3 Secretion.Infection and immunity · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Yersinia pestis causes the fatal respiratory disease pneumonic plague. Y. pestis recently evolved from the gastrointestinal pathogen Y. pseudotuberculosis; however, it is not known at what point Y. pestis gained the ability to induce a fulminant pneumonia. Here we show that the acquisition of a single gene encoding the protease Pla was sufficient for the most ancestral, deeply rooted strains of Y. pestis to cause pneumonic plague, indicating that Y. pestis was primed to infect the lungs at a very early stage in its evolution. As Y. pestis further evolved, modern strains acquired a single amino-acid modification within Pla that optimizes protease activity. While this modification is unnecessary to cause pneumonic plague, the substitution is instead needed to efficiently induce the invasive infection associated with bubonic plague. These findings indicate that Y. pestis was capable of causing pneumonic plague before it evolved to optimally cause invasive infections in mammals.
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