Evidence map›Paper›PMID 26123390›Full record

ArticleBrain imaging and behavior2016

Sparse temporally dynamic resting-state functional connectivity networks for early MCI identification.

Chong-Yaw Wee, Sen Yang, Pew-Thian Yap, Dinggang Shen, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chong-Yaw WeeImage Display, Enhancement, and Analysis (IDEA) Laboratory, Biomedical Research Imaging Center (BRIC) and Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sen YangDepartment of Computer Science and Engineering, Arizona State University, Tempe, AZ, USA.
Pew-Thian YapImage Display, Enhancement, and Analysis (IDEA) Laboratory, Biomedical Research Imaging Center (BRIC) and Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Dinggang ShenImage Display, Enhancement, and Analysis (IDEA) Laboratory, Biomedical Research Imaging Center (BRIC) and Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. dgshen@med.unc.edu.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Infant Brain Measurement and Super-Resolution Atlas ConstructionR01MH100217 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2013 to 2016
$2.3M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Fast, Robust Analysis of Large Population DataR01EB009634 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2011 to 2014
$1.3M
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
CIHRNIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIA NIH HHS U01 AG024904NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB009634NIMH NIH HHS R01 MH100217
6 · The paper itself

Abstract

In conventional resting-state functional MRI (R-fMRI) analysis, functional connectivity is assumed to be temporally stationary, overlooking neural activities or interactions that may happen within the scan duration. Dynamic changes of neural interactions can be reflected by variations of topology and correlation strength in temporally correlated functional connectivity networks. These connectivity networks may potentially capture subtle yet short neural connectivity disruptions induced by disease pathologies. Accordingly, we are motivated to utilize disrupted temporal network properties for improving control-patient classification performance. Specifically, a sliding window approach is firstly employed to generate a sequence of overlapping R-fMRI sub-series. Based on these sub-series, sliding window correlations, which characterize the neural interactions between brain regions, are then computed to construct a series of temporal networks. Individual estimation of these temporal networks using conventional network construction approaches fails to take into consideration intrinsic temporal smoothness among successive overlapping R-fMRI sub-series. To preserve temporal smoothness of R-fMRI sub-series, we suggest to jointly estimate the temporal networks by maximizing a penalized log likelihood using a fused sparse learning algorithm. This sparse learning algorithm encourages temporally correlated networks to have similar network topology and correlation strengths. We design a disease identification framework based on the estimated temporal networks, and group level network property differences and classification results demonstrate the importance of including temporally dynamic R-fMRI scan information to improve diagnosis accuracy of mild cognitive impairment patients.

Indexed as

AgedAlgorithmsBrainBrain MappingCase-Control StudiesCognitive DysfunctionConnectomeDatabases, FactualFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMembrane PotentialsNerve NetNeural PathwaysMild Cognitive Impairment (MCI)Resting-state functional MRI (R-fMRI)Sliding window correlationSparse temporal networksTemporal dynamicsTemporal smoothness

Identifiers

PMID26123390
PMCPMC4692725

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.